آزمایشات بالینی بهینه سازی شده پاسخ تطبیقی – تخصیص درمان متوالی مبتنی بر مسائل تصمیم گیری مارکوف Optimized Response-Adaptive Clinical Trials
- نوع فایل : کتاب
- زبان : انگلیسی
- نویسنده : Thomas Ondra
- چاپ و سال / کشور: 2015
- تعداد صفحه : 112
Description
Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences
