درک بیماری آلزایمر / Understanding Alzheimer’s Disease

درک بیماری آلزایمر Understanding Alzheimer’s Disease

  • نوع فایل : کتاب
  • زبان : انگلیسی
  • نویسنده : Inga Zerr
  • چاپ و سال / کشور: 2015
  • تعداد صفحه : 494

Description

This book spans a variety of approaches to address the complex problem of Alzheimer´s disease - what is the cause, is there a single pathogenetic pathways or are there many of them, how can we address the whole clinical spectrum of the disease, how can the disease be diagnosed early and reliable and which perspectives we have for prevention and treatment. The collection covers actual topics of interest for basic researcher, clinicians, epidemiologists and provides insight to various aspects of the disease. ----- Contents: -- Preface -- Section 1 Pathogenesis -- 1 Structure and Function of the APP Intracellular Domain in Health and Disease -- 2 Mechanism of Alzheimer Amyloid p-Protein Precursor Localization to Membrane Lipid Rafts -- 3 The Amyloidogenic Pathway Meets the Reelin Signaling Cascade: A Cytoskeleton Bridge Between Neurodevelopment and Neurodegeneration -- 4 y-Secretase — Regulated Signaling and Alzheimer's Disease -- 5 Phosphorylation ofTau Protein Associated as a Protective Mechanism in the Presence of Toxic, C-Terminally Truncated Tau in Alzheimer's Disease -- 6 Pin1 Protects Against Alzheimer's Disease: One Goal. Multiple Mechanisms -- 7 Alzheimer Disease and Metabolism: Role of Cholesterol and Membrane Fluidity -- Section 2 Diagnosis -- 8 Pre-Analytical and Analytical Critical Factors Influencing the High Variability of the Concentrations Levels of Alzheimer Disease Biomarkers in Cerebral Spinal Fluid -- 9 Candidate Bio-Markers of Alzheimer's Disease -- 10 Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease -- Section 3 Therapy -- 11 Potential Therapeutic Strategies to Prevent the Progression of Alzheimer to Disease States -- 12 Animal Assisted Therapy and Activities in Alzheimer's Disease -- Section 4 Epidemiology, Clinical Presentation and Prevention -- 13 Epidemiology of Alzheimer's Disease -- 14 Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular Dementia -- 15 Predicting Cognitive Decline in Alzheimer's Disease (AD): The Role of Clinical, Cognitive Characteristics and Biomarkers -- 16 Alzheimer's Disease and Diabetes -- 17 Prevention of Alzheimer's Disease: Intervention Studies
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