دیابت نوع 1 – پاتوژنز، ژنتیک و ایمنی درمانی Type 1 Diabetes

Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy



This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered. ---- Contents: -- Preface -- Part 1 Pathogenesis -- 1 Autoimmunity and Immunotherapy of Type 1 Diabetes -- 2 Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes -- 3 Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4 -- 4 The Role of T Cells in Type 1 Diabetes -- 5 Beta-Cell Function and Failure in Type 1 Diabetes -- 6 Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders -- 7 Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes -- 8 The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes -- 9 Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling -- Part 2 Pathogenesis - Virus -- 10 Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes -- Part 3 Pathogenesis – Environment -- 11 Environmental Triggers of Type 1 Diabetes Mellitus - Mycobacterium Avium Subspecies Paratuberculosis -- Part 4 Imaging -- 12 In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes -- 13 Imaging the Pancreatic Beta Cell -- Part 5 Therapy -- 14 Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus -- Part 6 Immunotherapy -- 15 Peptides and Proteins for the Treatment and Suppression of Type-1 Diabetes -- 16 Immunotherapy for Type 1 Diabetes - Preclinical and Clinical Trials -- 17 Type 1 Diabetes Immunotherapy - Successes, Failures and Promises -- 18 Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities -- 19 Autoantigen-Specific Immunotherapy -- 20 Multi-Component Vaccines for Suppression of Type 1 Diabetes -- Part 7 Beta Cell Replacement -- 21 Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes -- 22 Beta Cell Replacement Therapy -- Part 8 Genetics -- 23 Genetics of Type 1 Diabetes -- 24 The Genetics of Type 1 Diabetes -- 25 Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease -- 26 Genetics of Type 1 Diabetes -- 27 Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes -- 28 Genetic Determinants of Type 1 Diabetes