A feasibility study of percutaneous radiofrequency ablation  followed by radiotherapy in the management of painful  osteolytic bone metastases

A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases

  • نوع فایل : کتاب
  • زبان : انگلیسی
  • مؤلف : M. Di Staso & L. Zugaro & G. L. Gravina & P. Bonfili & F. Marampon & L. Di Nicola & A. Conchiglia & L. Ventura & P. Franzese & M. Gallucci & C. Masci
  • چاپ و سال / کشور: 2011

Description

Objectives To determine whether Radiofrequency Ablation (RFA) followed by Radiotherapy (RT) (RFA-RT) produces better palliation in terms of pain than RT alone in patients with osteolytic bone metastases. Methods Patients with solitary bone metastases and a pain score of least 5 or more on the VAS scale were selected. Fifteen patients were treated with RFA-RT (20 Gy delivered in 5 fractions of 4 Gy over 1 week) and were compared with a matched group (30 subjects) treated by RT. Results A complete response in terms of pain relief at 12 weeks was documented in 16.6% (5/30) and 53.3% (8/15) of the subjects treated by RT or RFA-RT, respectively (p=0.027). The overall response rate at 12 weeks was 93.3% (14 patients) in the group treated by RFA-RT and 59.9% (18 patients) in the group treated by RT (p=0.048). Although recurrent pain was documented more frequently after RT (26.6%) than after RFA-RT (6.7%) the difference did not reach statistical significance. The morbidity related to RT did not significantly differ when this treatment was associated with RFA. Conclusions Our results suggest that RFA-RT is safe and more effective than RT. The findings described here should serve as a framework around which to design future clinical trials.
Eur Radiol (2011) 21:2004–2010 DOI 10.1007/s00330-011-2133-3 Received: 15 December 2010 / Revised: 12 February 2011 / Accepted: 17 March 2011 / Published online: 1 May 2011
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