Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mariona Gimeno1,2*, Laila Darwich1,2, Ivan Diaz2, Eugenia de la Torre2, Joan Pujols2, Marga Martیn1,2, Shigeki Inumaru3, Esmeralda Cano2, Mariano Domi
- چاپ و سال / کشور: 2011
Description
The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-a. The four possible phenotypes based on the ability to induce IL-10 and/or TNF-a were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers.
Gimeno et al. Veterinary Research 2011, 42:9 http://www.veterinaryresearch.org/content/42/1/9
