Antinociceptive potential of the methanolic extract of  Microdermis puberula (Hook. F. Ex. Planch)

Antinociceptive potential of the methanolic extract of Microdermis puberula (Hook. F. Ex. Planch)

  • نوع فایل : کتاب
  • زبان : انگلیسی
  • مؤلف : Clement Jackson¹*, Herbert Mbagwu¹, Chidinma Okany², Emmanuel Bassey² and Iniunwana Udonkang³
  • چاپ و سال / کشور: 2011

Description

This study investigated the antinociceptive effects of the methanolic extract of the stem wood of Microdermis puberula (Hook. F. Ex. Planch) in Swiss albino mice of either sex with weights ranging from 17 to 25 g. Acetylsalicylic acid and morphine were used as standards for the antinociceptive tests while distilled water was used as control. Acetic acid - induced mouse writhing reflex test and hot plate test were used to determine peripheral and central pain inhibition respectively, using five groups of five animals for each model. The extract was administered in three dosages: 600, 1200 and 2400 mg/kg orally. Acetylsalicylic acid was administered at 100 mg/kg p.o., morphine at 10 mg/kg intraperitoneally and distilled water at 1 ml/kg p.o. Results showed that the extract of. Microdermis puberula, at 1200 and 2400 mg/kg significantly inhibited peripheral pain, compared with acetylsalicylic acid (p<0.05). The extract of Microdermis puberula, at a dose of 2400 mg/kg inhibited pain by increasing the pain threshold in the hot plate test 58.83%. These, therefore, suggest that the methanolic extract of Microdermis puberula possesses mild antinociceptive property. The phytochemical analyses of the extract showed the presence of flavonoids, saponins and cardiac glycosides. Results from the LD50 determination showed that a dose of 1412.5 mg/kg i.p. produced 50% death in mice.
Research In Pharmaceutical Biotechnology Vol. 3(5), pp. 53-56, May 2011 Available online at http://www.academicjournals.org/rpb ISSN 2141-2324 ©2011 Academic Journals Accepted 22 March, 2011
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