Tumor necrosis factor gene polymorphisms and susceptibility to rheumatoid arthritis in regional Tunisian population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : E. Fakhfakh Karray1*, I. Bendhifallah1, K. BenAbdelghani2, K. Hamzaoui1 and L. Zakraoui2
- چاپ و سال / کشور: 2011
Description
an unknown number of predisposing genes. The present study was undertaken in order to investigate the possible association between RA disease and the TNFagene promoter polymorphisms a-308A>G, a- 1031 T>C and the TNF polymorphism+252A>G (LTA252A>G) in the Tunisian population. We compared the distribution of TNF a-308; TNF a-1031 and LTA252 polymorphisms of TNF gene between 108 patients with RA and 226 healthy controls using PCR-RFLP analysis. No deviation from Hardy-Weinberg equilibrium was detected in either set of cases or controls. The LTA252 G allele frequency was significantly increased in RA patients (p = 0.01; 2 = 6.57 OR = 0.64, 95% CI = 0.45 to 0.91). The frequency of the LTA252GG genotype was significantly higher in RA patients than in healthy controls (p = 0.004; 2 = 8.15; OR = 1.99, 95% CI = 1.20 to 3.29). TNF-1031C allele frequency was significantly increased in patients with Remission RA activity (p = 0.0035; 2 = 8.52; OR = 6.18; 95% CI = 1.45 to 3.20). These results suggest that the LTA252A>G polymorphism of the TNF gene can be associated with the susceptibility to Rheumatoid Arthritis in our study group and the TNF-1031C allele seems to be involved in remission of RA activity. Therefore, the TNF molecule may have an important genetically and/or functionally implication in the pathogenesis of RA disease in Tunisian population.
Journal of Infectious Diseases and Immunity Vol. 3(2), pp. 30-35, February 2011 Available online at http://www.academicjournals.org/JIDI ISSN 2141-2375 ©2011 Academic Journals Accepted 31 January, 2011
