Aging of the genome : the dual role of the DNA in life and death
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jan Vijg
- ناشر : Oxford ; New York : Oxford University Press
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780191524585
Description
Preface; 1. Introduction; 2. The Logic of Aging; 3. Genome Structure and Function; 4. Genome Maintenance; 5. Genome Instability and Accelerated Aging; 6. The Aging Genome; 7. From Genome to Phenome; 8. A Genomic Limit to Life?; References and Glossary; Literature References
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms. It gives underlying biology of aging, driven by continuing demographic change.
