Target organ toxicity in marine and freshwater teleosts. / Volume 2, Systems
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniel Schlenk; William H Benson
- ناشر : London ; New York : Taylor & Francis
- چاپ و سال / کشور: 2001
- شابک / ISBN : 9780203361412
Description
Contents List of contributors vii Foreword viii Copyright acknowledgments ix 1 General mechanisms of toxicity DANIEL SCHLENK 1 Introduction 1 Disposition of xenobiotics 1 7 Exceeding capacity of cellular defense mechanisms 10 Specific cellular targets 12 Targets involving repair and cellular regeneration 19 Summary 23 2 Toxic responses of the nervous system 27 Introduction 27 Nervous system physiology 28 Chlorinated hydrocarbon insecticides 41 Pyrethroids 48 Anticholinesterase insecticides 54 Metals 63 Organics 66 Natural toxins 67 Conclusions 74 Chemical reactions of reactive intermediates/ultimate toxicants RUSSELL L.CARR AND JANICE E.CHAMBERS 3 Fish immunotoxicology: understanding mechanisms of action CHARLES D.RICE 97 Introduction 97 Innate, non-specific, and first-line defenses 10 Antigen processing and presentation for specific responses 109 Fish as models in biomedical research 114 Historical approaches to immunotoxicology 115 Mechanisms of action of some immunotoxicants 116 Autoimmunity and hypersensitivity: a frontier in fish immunotoxicology 119 The neuroendocrine-immune connection 122 Summary 127 4 Neurobehavioral toxicity in fish 141 Introduction 141 Neural basis of behavioral toxicity 144 Toxicant impacts on higher behavioral function 162 Ecologic relevance of behavior as a predictor of contaminant effects in the natural environment 164 Conclusions 166 5 Toxic responses of the reproductive system 177 Introduction 177 Hypothalamus-pituitary-gonadal axis 178 Gonadal development 182 Oocyte growth and maturation 186 Modes of nutrition 188 Targets for chemical toxicity 189 Egg-level effects 191 Alteration in egg yolk nutrients 191 Assessment of reproductive effects 195 Assessment of reproductive function 195 v EDWARD E.LITTLE AND SANDRA K.BREWER LISA D.ARCAND-HOY AND WILLIAM H.BENSON 3 Reproductive toxicity guidelines 196 Conclusions 199 Index 205 vi
