Principles and Methods of Toxicology 4Th Ed.

Part I: Principles of Toxicology 1 The Art, the Science, and the Seduction of Toxicology: An Evolutionary Development Joseph F.Borzelleca 1 2 The Use of Toxicology in the Regulatory Process Barbara D.Beck, Tracey M.Slayton, Edward J.Calabrese, Linda Baldwin, and Ruthann Rudel 23 3 Metabolism: A Determinant of Toxicity J.Donald deBethizy and Johnnie R.Hayes 77 4 Toxicokinetics: Pharmacokinetics in Toxicology Andrew Gordon Renwick 137 5 Physiologically Based Pharmacokinetic Modeling in Toxicology Kannan Krishnan and Melvin E.Andersen 193 6 The Toxicological Assessment of Pharmaceutical and Biotechnology Products Michael A.Dorato and Mary Jo Vodicnik 243 7 Statistics for Toxicologists Shayne C.Gad 285 8 Quantitative Extrapolations in Toxicology Joseph V.Rodricks, David W.Gaylor, and Duncan Turnbull 365 9 The Practice of Exposure Assessment Dennis J.Paustenbach 387 10 Epidemiology for Toxicologists Ralph R.Cook 449 Part II: Agents of Toxicity 11 Food-Borne Toxicants Chada S.Reddy and A.Wallace Hayes 491 12 Solvents and Industrial Hygiene Robert C.Spiker, Jr. and Gary B.Morris 531 13 Crop Protection Chemicals James T.Stevens, and Charles B.Breckenridge 565 14 Metals Jill C.Merrill, Joseph J.P.Morton, and Stephen D.Soileau 649 15 Ionizing Radiation Lorris G.Cockerham, Thomas L.Walden, Jr., Cham E.Dallas, Michael R.Landauer, and G.Andrew Mickley, Jr. 699 Part III: Methods of Toxicology 16 The Use of Laboratory Animals in Toxicologic Research William J.White 773 17 Genetic Toxicology David Brusick 819 18 Acute Toxicity and Eye Irritancy Louis C.DiPasquale and A.Wallace Hayes 853 19 Short-Term, Subchronic, and Chronic Toxicology Studies Nelson H.Wilson, Jerry F.Hardisty, and Johnnie R.Hayes 917 20 Principles of Testing for Carcinogenic Activity Gary M.Williams and Michael J.Iatropoulos 959 21 Principles of Clinical Pathology for Toxicology Studies Robert L.Hall 1001 22 Dermatotoxicology Howard Maibach and Esther Patrick 1039 23 Inhalation Toxicology Rudolph Valentine and Gerald L.Kennedy, Jr. 1085 24 Detection and Evaluation of Chemically Induced Liver Injury Gabriel L.Plaa and Michel Charbonneau 1145 25 Renal Methods for Toxicology Mary E.Davis and William O.Berndt 1189 26 Methods in Gastrointestinal Toxicology Carol T.Walsh 1215 27 Cardiovasular Physiology and Methods for Toxicology Thomas L.Smith, Louis Andrew Koman, Arnold T.Mosberg, and A.Wallace Hayes 1241 28 Assessment of Male Reproductive Toxicity Eric D.Clegg, Sally D.Perreault, and Gary R.Klinefelter 1263 29 Test Methods for Assessing Female Reproductive and Developmental Toxicology Mildred S.Christian 1301 30 Hormone Assays and Endocrine Function Michael J.Thomas and John A.Thomas 1383 31 Immunotoxicology: Effects of, and Response to, Drugs and Chemicals Jack H.Dean, Robert V.House, and Michael I.Luster 1415 32 Assessment of Behavioral Toxicity Bernard Weiss and Deborah A.Cory-Slechta 1451 33 Application of Isolated Organ Perfusion Techniques in Toxicology Harihara M.Mehendale 1529 34 Organelles As Tools in Toxicology Bruce A.Fowler, Mary L.Haasch, Kevin M.Kleinow, Katherine S.Squibb, and A.Wallace Hayes 1585 35 Analysis and Characterization of Enzymes and Nucleic Acids F.Peter Guengerich 1625 36 Modern Instrumental Methods for Studying Mechanisms of Toxicology Willam S.Caldwell, Gary D.Byrd, J.Donald deBethizy, and Peter A.Crooks 1689 37 Methods in Enviormental Toxicology Anne Fairbrother, Michael A.Lewis, and Robert E.Menzer 1759