Scientific frontiers in developmental toxicology and risk assessment
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : National Research Council (U.S.). Committee on Developmental Toxicology.; National Research Council (U.S.). Commission on Life Sciences.
- ناشر : Washington, DC : National Academy Press
- چاپ و سال / کشور: 2000
- شابک / ISBN : 9780309070867
Description
Recent Advances in Developmental Biology and the Promise of Genomics -- Committee's Approach to Its Charge -- Organization of the Report -- Developmental Defects and Their Causes -- Toxicant Exposure and Developmental Defects -- The Chemical Universe -- Current Practices for Assessing Risk for Developmental Defects and Their Limitations -- The Developmental Toxicity Risk Assessment Process -- Biomarkers -- Limitations in Developmental Toxicity Risk Assessments -- Mechanisms of Developmental Toxicity -- History of Developmental Toxicology: Growth of a New Field -- Principles of Teratology -- Mechanisms of Toxicity -- Human Genetics and the Human Genome Project -- Genotype, Phenotype, and Multifactorial Inheritance -- Polymorphisms -- The Human Genome Project -- Recent Developments in Molecular Epidemiology -- Recent Advances in Developmental Biology -- A Brief History of Developmental Biology -- Advances in Developmental Biology -- Using Model Animals to Assess and Understand Developmental Toxicity -- Model Organisms and the Genetic Approach -- The Major Model Animals for Genetic Analysis -- Possible Applications of Model Animal Research to Developmental Toxicology -- Gene Expression as Determined by In Vitro and Engineered Cell Technologies -- A Multilevel Approach to Improving Risk Assessment for Developmental Toxicity -- The Multidisciplinary, Multilevel, Interactive Approach -- Conclusions in Relation to the Charge -- Recommendations -- Database Descriptions -- Signaling Pathways.
