Evaluating chemical and other agent exposures for reproductive and developmental toxicity
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : National Research Council (U.S.). Subcommittee on Reproductive and Developmental Toxicology.
- ناشر : Washington, D.C. : National Academy Press,
- چاپ و سال / کشور: 2001
- شابک / ISBN : 9780309073165
Description
SUMMARY 1 1 INTRODUCTION 11 Subcommittee Task 20 Organization of the Report 22 2 THE EVALUATIVE PROCESS: PART I. ASSESSING THE AVAILABLE DATA 24 Principles and Objectives 24 General Description 30 Details of the Evaluative Process 31 3 THE EVALUATIVE PROCESS: PART II. INTEGRATION OF TOXICITY AND EXPOSURE INFORMATION 57 Interpretation of Toxicity Data 57 Quantitative Evaluation 64 Summary, 79 4 INCOMPLETE OR INSUFFICIENT DATA SETS 81 Principles to Minimize Risk 81 Practical Application 83 Reducing Uncertainty 845 RECOMMENDATIONS 86 General Recommendations 86 Research Recommendations 89 REFERENCES 92 APPENDIXES A APPLICATION OF THE RECOMMENDED EVALUATIVE PROCESS TO SPECIFIC CHEMICALS 117 B ASCERTAINING INFORMATION ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF AGENT EXPOSURES 168 C HUMAN STUDY DESIGNS 198 D EXPERIMENTAL ANIMAL AND IN VITRO STUDY DESIGNS 206
