Toxicity-pathway-based risk assessment : preparing for paradigm change : a symposium summary
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ellen K Mantus; National Research Council (U.S.). Standing Committee on Risk Analysis Issues and Reviews.; National Research Council (U.S.). Board on
- ناشر : Washington, D.C. : National Academies Press
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9780309154222
Description
SUMMARY OF THE SYMPOSIUM............................................................... 3 APPENDIXES A Biographic Information on the Standing Committee on Risk Analysis Issues and Reviews ...................................................................... 53 B Biographic Information on the Planning Committee for a Symposium on Toxicity-Pathway-Based Risk Assessment........................ 59 C Symposium Agenda.................................................................................... 63 D Biographic Information on the Speakers and Panelists for a Symposium on Toxicity-Pathway-Based Risk Assessment........................ 70 E Symposium Presentations ........................................................................... 83 F Poster Abstracts. ......................................................................................... 84 TABLES AND FIGURES TABLES 1 Options for Future Toxicity-Testing Strategies Considered by the NRC Committee on Toxicity Testing and Assessment of Environmental Agents, 7 2 Phased Development of ToxCast Program, 16 3 Types of ToxCast Assays, 17 FIGURES 1 Components of the vision described in the report, Toxicity Testing in the 21st Century: A Vision and a Strategy, 83 DNA sequencing output, 11 4 Throughput potential for data acquisition as related to levels of biologic organization, 13 5 Illustration of bioactivity profiling using high-throughput technologies to screen chemicals, 14 6 Overview of chemical registration for REACH, 21 7 Integration of new approaches for toxicology, 22 8 Dosimetry considerations in cell systems, 28 9 What do cells see? Protein adsorption by nanomaterials is a universal phenomenon in biologic systems, 28 10 Example of gene ontology for DNA metabolism, a biologic process, 31 11 Framework for interpretation of dose- and time-dependent genomic data, 32 12 Integrated data provide more comprehensive and accurate network reconstruction, 36 13 Illustration of the development of modular network models, 37 14 Interaction network that can be used to associate environme
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