Tumor-induced immune suppression : mechanisms and therapeutic reversal
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dmitry I Gabrilovich; Arthur A Hurwitz
- ناشر : New York, NY : Springer
- چاپ و سال / کشور: 2008
- شابک / ISBN : 9780387691183
Description
Introduction.- Mechanisms and Therapeutic Reversal of the Defects in T-Cell Function in Cancer.- Molecular Mechanisms of Tumor-Associated T-Cell Tolerance.- T-Cell Tolerance.- T-Cell Inhibitory Molecules and Suppression of T-Cell Function In Cancer.- CTLA-4 and T-Cell Tolerance in Cancer.- Regulatory T-Cells in Cancer.- T-Cell Apoptosis in Cancer.- Defects in Dendritic Cell Differentiation in Cancer and Tumor Escape.- Dendritic Cells With Tolerogenic Potential in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in Induction of T-Cell Tolerance.- Macrophages and Tumor Development.- Immature Myeloid Suppressor Cells in Tumor-Induced T-Cell Tolerance.- Arginin Metabolism as A Critical Element of Tumor Suppression in Cancer.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Cytokine Production in Cancer and their Negative Effect on Immune Response.- Inflammation and Immune Abnormalities in Cancer.- Tumor Stroma and Antitumor Immune Response.- Tumor Associated Immune Defects. Where are Now and Where are We Going.
This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses new mechanisms that have never been discussed in a monograph before
