Cannabinoids and the brain : with 16 tables
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Attila Köfalvi
- ناشر : New York, NY : Springer
- چاپ و سال / کشور: 2008
- شابک / ISBN : 9780387743486
Description
Part I Molecular biology, pharmacology, anatomy, and physiology of the encocannabinoid and related lipidergic signaling systems in the brain: An historical introduction to the endocannabinoid and endovanilloid systems.-Biosynthesis of anandamide and 2-arachidonolyglycerol.-Removal of endocannabinoids by the body-mechanisms and therapeutic possibilities.-Other cannabimimetic lipid signaling molecules.-CB1 cannabinoid receptors: molecular biology, second messenger coupling and polarized trafficking in neurons.-CB2 cannabinoid receptors: molecular, signaling and trafficking properties.-CB1 and CB2 receptor pharmacology.-Functional molecular biology of the TRPV1 channel.-Alternative interacting sites and novel receptors for cannabinoid ligands.-Anatomical distribution of receptors, ligands and enzymes in the brain and in the spinal cord: circuitries and neurochemistry.-Endocannabinoids at the synapse-retrograde signaling and presynaptic plasticity in the brain.-Endocannabinoid functions in neurogenesis, neural migration and specification.-Part II The endocannabinoid system in clinical neuroscience and experimental neursopsychiatry: Cannabinoids in the management of nausea and vomiting.-Endocannabinoids in energy homeostasis and metabolic disorders.-Cannabinoids and neuroprotection.-Neuroinflammation and the glial endocannabinoid system.-Targeting cannabinoid receptors in brain tumors.-Cannabinoids for the control of multiple sclerosis.-Endocannabinoids in Alzheimer's disease.-The endocannabinoid system as a therapeutic target in epilepsy.-The endocannabinoid system in the physiology and pathology of the basal ganglia.-The endocannabinoid system is a major player in schizophrenia.-The cannabinoid controversy: cannabinoid agonists and antagonists as potential novel therapies for mood disorders.-Role of cannabinoid receptors in anxiety disorders.
