Clinical Nephrotoxins : Renal Injury from Drugs and Chemicals

GENERAL 1 1 Clinical relevance 3 George A. Porter 2 Drug-associated acute kidney injury in the intensive care unit 29 Mitchell H. Rosner and Mark D. Okusa 3 Renal handling of drugs and xenobiotics 43 Marc E. De Broe and Françoise Roch-Ramel 4 Pharmacological aspects of nephrotoxicity 73 Marisa D. Covington and Rick G. Schnellmann 5 Pharmacovigilance: from signal to action 85 Hubert G. Leufkens and Antoine C. Egberts 6 Urinary biomarkers and nephrotoxicity 91 William F. Finn and George A. Porter 7 Toxin-induced immunological renal disease 131 Lucette Pelletier, Abdelhadi Saoudi and Gilbert Fournié 8 Cellular mechanisms of nephrotoxicity 155 Istvan Arany, Gur P. Kaushal, Didier Portilla, Judit Megyesi, Peter M. Price and Robert L. Safirstein 9 Animal models for the assessment of acute renal dysfunction and injury 173 Zoltan H. Endre and Charles L. Edelstein 10 Renal cell culture models: contribution to the understanding of nephrotoxic mechanisms 223 Paul Jennings, Christian Koppelstنtter, Judith Lechner and Walter Pfaller 11 Use of dialytic therapies for poisoning 251 James F. Winchester, Nikolas Harbord and Donald A. Feinfeld TABLE OF CONTENTS VI Table of Contents B SPECIFIC DRUGS 265 12 Aminoglycosides and vancomycin 267 Brian S. Decker and Bruce A. Molitoris 13 Beta-lactam antibiotics 293 Constantin Cojocel 14 Amphotericin B 323 Nathalie K. Zgheib, Blair Capitano and Robert A. Branch 15 Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones 353 Gabriel N. Contreras, Cristiane Mocelin Carvalho, Jorge M. Diego, Decio Carvalho and Isabel Espinal 16 Antiviral agents 383 Jeffrey S. Berns, Alden Doyle and Nishaminy Kasbekar 17 Analgesics and 5-aminosalicylic acid 399 Monique M. Elseviers and Marc E. De Broe 18 Non-steroidal anti-inflammatory drugs 419 Ali J. Olyaei, Andrew Whelton, Til Sturmer and George A. Porter 19 Gold salts, D-penicillamine and allopurinol 459 Shiro Ueda and George A. Porter 20 Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists 481 Paul E. De Jong 21 Diuretics and alcohol ingestion 495 Sheldon C. Chaffer and Jules B. Puschett 22 Anticancer drugs 511 Corinne Isnard-Bagnis, Vincent Launay-Vacher, Svetlana Karie and Gilbert Deray 23 Anesthetic agents 537 Per-Olof Jarnberg 24 Bisphosphonates and the kidney 547 Jonathan Green 25 Proton pump inhibitors: acute interstitial nephritis and other renal effects 567 Ursula C. Brewster and Mark A. Perazella 26 Oral sodium phosphate bowel purgatives and acute phosphate nephropathy 579 Glen S. Markowitz 27 Illicit drug abuse and renal disease 595 Cheryl L. Kunis, Nidhi Aggarwal and Gerald B. Appel 28 Nephrotoxicity of calcineurin and mTOR inhibitors 617 Emmanuel A. Burdmann and William M. Bennett 29 Immunomodulators: interleukins, interferons, and IV immunoglobulin 683 Joris J. Roelofs, Daniel Abramowicz and Sandrine Florquin VII Table of Contents 30 Imaging agents 699 Christiane M. Erley, Ihab M. Wahba and George A. Porter 31 Lithium-associated kidney effects 725 Daniel Batlle, Edgar V. Lerma, Parveen Naaz and Santosh Hakkapakki 32 Oxalate 749 Anja Verhulst and Marc E. De Broe 33 Herbal remedies containing aristolochic acid and mushroom nephrotoxicity 579 Frédéric Debelle, Marie-Carmen Muniz-Martinez, Jean-Louis Vanherweghem and Joëlle Nortier C ENVIRONMENTAL AND OCCUPATIONAL NEPHROTOXINS 771 34 Lead nephropathy 773 Richard P. Wedeen 35 Cadmium-induced renal effects 785 Gunnar F. Nordberg, Teruhiko Kido and Harry A. Roels 36 Mercury-induced renal effects 811 Bruce A. Fowler, Margaret H. Whittaker and Carl-Gustaf Elinder 37 Organic solvents, silicon-containing compounds and pesticides 827 Patrick C. D’Haese, Monique M. Elseviers, Muhammed Yaqoob and Marc E. De Broe 38 Balkan nephropathy 843 Ljubica Djukanovic and Zoran Radovanovic 39 Nephrotoxins in Africa 859 Charles Swanepoel, Marc Blockman and Joe Talmud 40 Paraphenylene diamine hair dye poisoning 871 Mohamed I. Hamdouk, Mohamed B. Abdelraheem, Ahbab A. Taha, Mohamed Benghanem and Marc E. De Broe D THE RENAL FAILURE PATIENT 881 41 Trace metal disturbances in end-stage renal failure patients 883 Patrick C. D’Haese 42 Smoking and the kidney 895 Eberhard Ritz 43 Star fruit 901 Miguel Moysés Neto, Ruither O. Carolino, Norberto P. Lopes and Norberto Garcia-Cairasco 44 Drug dosage in renal failure 913 Ali J. Olyaei and William M. Bennett LIST OF ABBREVIATIONS 945 INDEX 951