Toxicology of the pancreas

1 John W. Lin and Steven D. Leach 2 Koji Yamaguchi, Masahiko Kawamoto, and Masao Tanaka 3 Dale E. Bockman, Tomoko Inagaki, and Toshio Morohoshi 4 Yukio Mikami, Kazunori Takeda, Takuro Murakami, and Seiki Matsuno 5 Centroacinar Cells — A Neglected Essential Element of Parviz M. Pour 6 William Y. Chey and Ta-min Chang 7 Jens Standop, Alexis Ulrich, and Parviz M. Pour 8 Alexis Ulrich, Jens Standop, and Parviz M. Pour 9 Vay Liang W. Go and Yu Wang 10 Daniel S. Longnecker Developmental Biology of the Vertebrate Pancreas........................... 1 Gross Anatomy of the Pancreas ....................................................... 35 Fine Structure of the Pancreas.......................................................... 55 Vascular Anatomy of the Pancreas.................................................... 75 the Pancreas....................................................................................... 91 Physiology of Exocrine Pancreas.................................................... 109 Drug-Metabolizing Enzymes in the Human Pancreas.................. 139 Drug-Metabolizing Enzymes in the Pancreas of Animals............. 163 Pancreatic Exocrine-Endocrine Interaction.................................... 175 Nutritional Requirements of the Pancreas..................................... 191 xviii  Toxicology of the Pancreas 11 Activity of Pancreatic Secretory Trypsin Inhibitor Is Masahiko Hirota 12 Mahefatiana Andrianifahanana, Nicolas Moniaux, and Surinder K. Batra 13 Ahmed Guweidhi, Jِrg Kleeff, Parviz M. Pour, Markus W. Büchler, and Helmut Friess 14 Toxicology of Natural Hormones and Hormonelike Michael L. Steer 15 Stephan L. Haas, Alexander Schneider, and Manfred V. Singer 16 Chronic Pancreatitis: The Initial Tissue Damage and the Günter Klِppel 17 Chemically Induced Exocrine Degeneration, Atrophy, Abraham Nyska, Amy E. Brix, Michael P. Jokinen, Donald M. Sells, Michael E. Wyde, Denise Orzech, Joseph K. Haseman, Gordon Flake, and Nigel J. Walker 18 Chronic Pancreatic Toxicity — Role of Stem Cells in the M. Sambasiva Rao and Janardan K. Reddy 19 Environmental Factors and Exocrine Pancreatic Albert B. Lowenfels and Patrick Maisonneuve 20 Environmental Determinants of Exocrine Pancreatic Eric J. Duell, Paige M. Bracci, and Elizabeth A. Holly 21 Parviz M. Pour 22 Toxicity of Tobacco-Specific N-Nitrosamines.............................. Bogdan Prokopczyk, Dietrich Hoffmann, and Karam El-Bayoumy 23 Kazuichi Okazaki Essential against Pancreatotoxic Factors....................................... 207 Pathological Perspectives of Pancreatic Mucins............................ 217 Growth Factors in Pancreatic Diseases.......................................... 243 Chemicals ...................................................................................... 283 Alcohol and Pancreatitis................................................................. 307 Resulting Fibrosis Patterns............................................................. 329 and Arterial Diseases in Rats......................................................... 343 Conversion of Pancreas to Liver..................................................... 355 Disease ............................................................................................ 379 Cancer ............................................................................................. 395 The Effects of Nutrients on Pancreatic Malignancy..................... 423 433 Autoimmune Pancreatitis — Recent Concept............................... 459 Contents  xix 24 Role of Genetic Factors in Inflammatory Diseases of F. Ulrich Weiss and Markus M. Lerch 25 Genetic Disorders Associated with Exocrine and Henry T. Lynch, Carolyn A. Deters, Jane F. Lynch, and Randall Brand 26 Cystic Fibrosis of the Pancreas — The Disease and Its Ajay P. Singh and Surinder K. Batra 27 Mehmet Yalniz and Parviz M. Pour 28 Reid Aikin, Stephen Hanley, Mark Lipsett, and Lawrence Rosenberg 29 Pancreatic Cancer and Diabetes — Cellular Origin of Nicolas Moniaux, Krishan K. Pandey, Parviz M. Pour, and Surinder K. Batra the Pancreas.................................................................................... 475 Endocrine Pancreatic Tumors..................................................... 491 Manifestations.................................................................................. 519 Toxicology of the Endocrine Pancreas........................................... 541 Alterations of the Endocrine Pancreas........................................... 579 Adeonocarcinoma............................................................................ 645 Index......................................................................................................... 671