Teratogens : chemicals which cause birth defects

TABLE OF CONTENTS INTRODUCTION. Vera Kolb Meyers CHAPTER 1. H.B. Morgan, G.S. Danford, F.M. Holland, K.C. Miller, E.T. Owens, B.E. Ricci. S.Y. Uppuluri. and J.S. Wassom: TERATOGENIC POTENTIAL OF CHEMICALS 1. Introduction 2. Data Bases Specializing in Teratology 3. Secondary Literature Sources Containing Toxicological Information 4. Reference Books 5. Teratology Information Services 6. Conclusion HOW TO OBTAIN INgORMATION ABOUT THE CHAPTER 2. Vera Kolb Meyers: REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES AS A SOURCE FOR COMPILING A LIST OF TERATOGENS Appendix I Appendix I1 (These Appendices contain a list of 4,974 chemicals from RTECs which cause reproductive effects.) CHAPTER 3. Kari Hemminki and Marja-Liisa Lindbohm: REPRODUCTIVE HAZARDS IN INDUSTRY: IDENTIFICATION AND PREVENTION 1. Introduction 2. Mechanisms of Reproductive Toxicity 3. Evidence on Occupational Hazards 4. Prevalent Exposures 5 . Clues from Experimental Data Conclusions CHAPTER 4, Doris K. Kolb: TERATOGENIC CHEMICALS IN UNDERGRADUATE GENERAL CHEMISTRY LABORATORIES Potential Teratogens in General Chemistry Laboratory Manuals 1. Potentially Teratogenic Metals 2. Potentially Teratogenic Inorganic Compounds 3. Potentially Teratogenic Organic Compounds 4. Potentially Teratogenic Gases Conclusions 1 6 6 7 21 33 34 36 42 48 223 239 239 239 240 241 243 245 247 *By acceptance of this article, the publisher or recipient acknowledges the U.S. Government's right to retain a nonexclusive. royalty-free license in and to any copyright covering this article. X CHAPTER 5. Blaine C. McKusick: SAFE HANDLING OF TERATOGENIC CHEMICALS 1. 2. 3. Handling Teratogens in the Laboratory Handling Teratogens in Inqustrial Operations Handling Teratogens in the Community CHAPTER 6. USE OF RWjISTEFtED DATA IN STUDIES OF OCCUPATIONAL EXPOSURE AND PREGNANCY OUTCOME 1. Introduction 2. Study Strategy 3. Registers on Pregnancy Outcome 4. Registers on Occupational Groups 5. Examples 6. Conclusions Marja-Liisa Lindbohm and Kari Hemminki: CHAPTER 7. M. Mirmiran and S. De Boer: LONG-TERM EFFECTS OF CHEMICALS ON DEVELOPING BRAIN AND BEHAVIOR 1. 2. 3. Derangements of Brain Development 4. 5. 6 . Chemical Hazards for Developing Brain and Behavior Passage of Potentially Noxious Substances into the Fetus and Infant Effects on Behavioral State Development Experimental Effects of Chemicals on Behavioral Development Methodological Aspects of Neurobehavioral Teratology CHAPTER 8 . M.J. Kland: TERATOGENICITY OF PESTICIDES AND OTHER ENVIRONEMTAL POLLUTANTS 1. 2. 3. 4. 5. 6. 7. 9 . a. Introduction The Organohalogen Aromatic and Cyclic Pesticides and Related Compounds The Haloalkanes and Related Pesticides Miscellaneous Halogenated and Other Alkanes and Alkenes of Industrial Importance Miscellaneous Insecticides: Fumigants Organophosphorous Pesticides and Related Compounds Carbamate Pesticides and Related Compounds Miscellaneous Pesticides Summary 260 260 260 262 264 265 269 315 319 365 366 376 382 390 402 405 SUBJECT INDEX 4 65