Computational Toxicology : Risk Assessment for Pharmaceutical and Environmental Chemicals.
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sean Ekins
- ناشر : Hoboken : John Wiley & Sons,
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780470145883
Description
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction. 7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity.
In silico modeling for toxicology provides effective pre-screening for chemicals in pharmaceutical discovery and the environment. This work discusses the validation of such models for regulatory purposes, the validation criteria, and other requirements for regulatory acceptance. It also looks at QSAR models, environmental modeling, among others.
