Oxygen/nitrogen radicals : lung injury and disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Val Vallyathan; Xianglin Shi, Ph. D.; Vincent Castranova
- ناشر : New York : Marcel Dekker, Inc
- چاپ و سال / کشور: 2004
- شابک / ISBN : 9780824748746
Description
1. Reactive oxygen/nitrogen species : generation and reactions in the lung -- 2. Oxidative stress/antioxidant status in health and disease -- 3. Reactive oxygen species in the activation and regulation of intracellular signaling events -- 4. Mediators of lung inflammation : role of reactive oxygen and nitrogen species -- 5. Pulmonary complications of chronic granulomatous disease -- 6. Genotoxic and carcinogenic mechanisms of mineral fibers : role of reactive oxygen species -- 7. Influence of mineral dust surface characteristics and generation of reactive species -- 8. Oxygen/nitrogen radicals and silica-induced diseases -- 9. Asbestosis and asbestos-related cancers : role of reactive oxygen and nitrogen species -- 10. Interactions of exogenous or evoked reactive oxygen species and inhaled particles in the lung -- 11. Smoking-induced inflammation, injury and disease : molecular mechanisms -- 12. Respiratory health effects of ambient air pollution particles : role of reactive species -- 13. Ozone-induced lung injury : role of macrophages and inflammatory mediators -- 14. Oxidative stress in chronic obstructive pulmonary disease -- 15. Chronic obstructive pulmonary disease : mechanisms of disease development and prevention strategies with antioxidants -- 16. Acute respiratory distress syndrome and oxidative stress : mechanisms of disease development and opportunities for antioxidant prevention -- 17. Asthma and oxidative stress -- 18. Cellular responses of the lungs to hyperoxia -- 19. Vanadium and chromium-induced cell signal transduction -- 20. Molecular mechanisms of oxidant-induced pulmonary carcinogenesis.
(Publisher-supplied data) The first state-of-the-art book dealing specifically with lung injury induced by oxygen and nitrogen radicals, this detailed treatise discusses molecular, cellular, and mechanistic events leading to pathophysiological outcomes; the role of oxidant species in the induction of these events; and potential therapeutic avenues targeting such molecular pathways. Important issues regarding oxidative stress involvement in the initiation and progression of pulmonary diseases-including diseases caused by occupational and environmental inhalation of toxicants-are discussed in the context of amelioration by antioxidants.
