Toxicology of the gastrointestinal tract
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shayne C Gad
- ناشر : Boca Raton : CRC Press,
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780849327933
Description
Introduction: the gastrointestinal (GI) tract as a barrier and as an absorptive and metabolic organ / Shayne C. Gad -- Methods for the analysis of gastrointestinal function / Robin C. Guy -- Safety pharmacology and the GI tract / Henry I. Jacoby -- Gastronintestinal tract development and its importance in toxicology / Joseph V. Rodricks, Allison A. Yates, and Claire L. Kruger -- The GI tract as major route of pharmaceutical administration / Robert W. Kapp, Jr. -- Gastrointestinal function and toxicology in canines / Charles Spainhour -- Absorption of macromolecules by mammalian intestinal epithelium / Shayne C. Gad -- Peyer's patch epithelium: an imperfect barrier / Gary R. Burleson and Florence G. Burleson -- Alteration of intestinal function by xenobiotic exposure: animal models / Shayne C. Gad -- Intestinal absorption and metabolism of xenobiotics in laboratory animals / William J. Brock -- Normal and abnormal intestinal absorption by humans / David W. Hobson and Valerie L. Hobson -- Intestinal absorption and metabolism of xenobiotics in humans / William J. Brock and David W. Hobson.
Focuses on the specifics of the mechanisms and adverse effects of xenobiotic agents and pharmaceuticals on the structure and function of the GI tract. This work offers an overview of the gastrointestinal system involved in the toxicity of exogenous agents. It describes the role of absorption and metabolism in the systemic toxicity of toxic agents.
