Toxicokinetics and risk assessment
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : John C Lipscomb; Edward V Ohanian
- ناشر : New York : Informa Healthcare
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780849337222
Description
Overview of approach to noncancer risk assessment / Lynne Haber -- Guidance for the development of chemical-specific adjustment factors / Bette Meek and Andrew Renwick -- Derivation and modeling of mechanistic data for use in risk assessment / Ronald L. Melnick -- Empirically observed distributions of pharmacokinetic and pharmacodynamic variability in humans / Dale Hattis and Meghan Keaney Lynch -- Use of classical pharmacokinetic evaluations in drug development and safety assessment / Rakesh Dixit and Peter Ward -- Considerations for applying physiologically based pharmacokinetic models in risk assessment / Chadwick Thompson ... [et al.] -- Considerations of design and data when developing physiologically based pharmacokinetic models / Peter J. Robinson ... [et al.] -- In silico predictions of partition coefficients for physiologically based pharmacokinetic models / Kannan Krishnan, Andy Nong and Sami Haddad -- In vitro to in vivo extrapolation of metabolic rate constants for physiologically based pharmacokinetic models / Gregory L. Kedderis -- Use of physiologically based pharmacokinetic modeling to evaluate implications of human variability / P. Robinan Gentry and Harvey J. Clewell III -- Developmental aspects of children's pharmacokinetics / Gary Ginsberg ... [et al.] -- Sensitive populations and risk assessment / Michael Dourson and Daniel Drinan -- Statistical issues in physiologically based pharmacokinetic modeling / Weihsueh A. Chiu -- Drug development and the use of pharmacokinetics/toxicokinetics in selecting the first does of systemically administered drugs in humans / Abigail Jacobs -- Pharmacokinetic/physiologically based pharmacokinetic models in integrated risk information systems assessments / Robert s. DeWoskin ... [et al.].
