Principles of toxicology testing
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Frank A Barile
- ناشر : Boca Raton : CRC Press
- چاپ و سال / کشور: 2008
- شابک / ISBN : 9780849390258
Description
Effects of chemicals -- Toxicokinetics -- Risk assessment and regulatory toxicology -- Descriptive animal toxicology tests -- Acute toxicology testing -- Subchronic and chronic toxicology testing -- Acute dermal and ocular toxicity testing -- Toxicity testing for fertility and reproduction -- Carcinogenicity and mutagenicity testing in vivo -- Toxicology testing in vitro -- Cell culture methodology -- Cell culture methods for acute toxicology testing -- Toxicokinetic studies in vitro -- Mutagenicity testing in vitro -- Reproductive and teratogenicity studies in vitro -- High throughput screening and microarray analysis -- Experimental design and statistics -- Standardization and validation of alternative methods -- Applications of alternative models for toxicology testing.
Compares the principles of animal toxicology testing with in vitro alternative methods to highlight the importance of each for interpretation of the significance and relevance of the other. This book introduces the fundamentals of the toxicology, toxicokinetics, and human risk assessment.
