Molecular nutrition

Contributors ix Preface xi PART 1: METHODS IN MOLECULAR NUTRITION RESEARCH 1 Genomics and Beyond 1 Ji Zhang 2 Perspectives in Post-genomic Nutrition Research 13 Hannelore Daniel PART 2: CELLULAR NUTRIENT HOMEOSTASIS, PROLIFERATION AND APOPTOSIS 3 Molecular Physiology of Plasma Membrane Transporters for Organic Nutrients 21 Hannelore Daniel 4 Intracellular Trafficking and Compartmentalization of Vitamins and Their Physiologically Active Forms 43 Donald B. McCormick 5 Nutrient Homeostasis in Proliferating Cells 61 Janos Zempleni 6 Nutrients and Apoptosis 73 John C. Mathers PART 3: ROLES FOR NUTRIENTS IN SIGNAL TRANSDUCTION, GENE EXPRESSION AND PROTEOLYSIS 7 Glucose Regulation of Gene Expression in Mammals 91 Fabienne Foufelle and Pascal Ferré v8 Amino Acid-dependent Control of Transcription in Mammalian Cells 105 Michael S. Kilberg, Van Leung-Pineda and Chin Chen 9 Fatty Acids and Gene Expression 121 Ulrike Beisiegel, Joerg Heeren and Frank Schnieders 10 Role of RARs and RXRs in Mediating the Molecular Mechanism of Action of Vitamin A 135 Dianne R. Soprano and Kenneth J. Soprano 11 Regulation of Gene Expression by Biotin, Vitamin B6 and Vitamin C 151 Krishnamurti Dakshinamurti 12 Selenium and Vitamin E 167 Alexandra Fischer, Josef Pallauf, Jonathan Majewicz, Anne Marie Minihane and Gerald Rimbach 13 Sphingolipids: a New Strategy for Cancer Treatment and Prevention 187 Eva M. Schmelz 14 The Health Effects of Dietary Isoflavones 201 Thomas M. Badger, Martin J.J. Ronis and Nianbai Fang 15 Mechanisms of Ubiquitination and Proteasome-dependent Proteolysis in Skeletal Muscle 219 Didier Attaix, Lydie Combaret, Anthony J. Kee and Daniel Taillandier PART 4: NUCLEIC ACIDS AND NUCLEIC ACID-BINDING COMPOUNDS 16 Diet, DNA Methylation and Cancer 237 Judith K. Christman 17 Biotinylation of Histones in Human Cells 267 Janos Zempleni 18 Niacin Status, Poly(ADP-ribose) Metabolism and Genomic Instability 277 Jennifer C. Spronck and James B. Kirkland PART 5: MOLECULAR EVENTS AFFECT PHYSIOLOGY 19 Assembly of Triglyceride-transporting Plasma Lipoproteins 293 Joan A. Higgins 20 Regulation of Cellular Cholesterol 309 Ji-Young Lee, Susan H. Mitmesser and Timothy P. Carr 21 2002 Assessment of Nutritional Influences on Risk for Cataract 321 Allen Taylor and Mark Siegal 22 Nutrition and Immune Function 349 Parveen Yaqoob and Philip C. CalderPART 6: FOODS 23 Molecular Mechanisms of Food Allergy 369 J. Steven Stanley and Gary A. Bannon 24 Safety Assessment of Genetically Modified Foods 381 Steve L. Taylor Index 395