Immunotoxin methods and protocols
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Walter A Hall
- ناشر : Totowa, N.J. : Humana Press
- چاپ و سال / کشور: 2001
- شابک / ISBN : 9780896037755.
Description
pt. 1. Immunotoxin construction and development -- Development and activities of the BR96-doxorubicin immunoconjugate -- CD7-specific single chain Fv immunotoxins: design and expresion -- Recombinant fusion toxins directed against the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor -- Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immuonotoxins -- Purification and conjugation of type 1 ribosome-inactivating proteins -- Comparison of immuotoxins bearing a single saporin molecule with multiple toxin conjugates -- Modulation of growth factor receptor expression by irradiation for immunotoxin targeting -- Quantification of immunotoxin number for complete therapeutic response -- In vitro studies of ricin A-chain-induced vascular leak syndrome -- pt. 2. Oncologic applications of immunotoxins -- Immunotoxin treatment of brain tumors -- Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors -- Bispecific monoclonal antibiodies for the targeting of type 1 ribosome-inactivating proteins against hematological malignancies -- Tyrosine kinaseinhibitors against EGF receptor-positive malignancies -- Targeting tumor vasculature using VEGF-toxin conjugates -- Gene therapy with immunotoxins -- pt. 3. Alternative applications of immunotoxins -- Effects of selective immunotoxic lesions on learning and memory -- Targeting toxins to neural antigens and receptors -- In vivo testing of anti-HIV immunotoxins
