Fatty acids : physiological and behavioral functions

Series Editor Page .......................................................................................................... v Foreword by Ralph Holman, PhD ................................................................................. vii Foreword by William Lands, PhD .................................................................................. ix Preface ........................................................................................................................ xvii Contributors ............................................................................................................... xxiii Part I Basic Mechanisms 1 Evolutionary Aspects of Diet: Essential Fatty Acids....................... 3 Artemis P. Simopoulos 2 Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition ................................................................................ 23 Drake C. Mitchell and Burton J. Litman 3 Role of Docosahexaenoic Acid in Determining Membrane Structure and Function: Lessons Learned from Normal and Neoplastic Leukocytes ......................................................... 41 Laura J. Jenski and William Stillwell 4 Effects of Essential Fatty Acids on Voltage-Regulated Ionic Channels and Seizure Thresholds in Animals .................. 63 Robert A. Voskuyl and Martin Vreugdenhil 5 Role of Dietary Fats and Exercise in Immune Functions and Aging .................................................................................... 79 Jaya T. Venkatraman and David Pendergast Part II Phospholipid and Fatty Acid Composition and Metabolism 6 On the Relative Efficacy of ????-Linolenic Acid and Preformed Docosahexaenoic Acid as Substrates for Tissue Docosahexaenoate During Perinatal Development ................................................... 99 Meng-Chuan Huang and J. Thomas Brenna 7 Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System .............................................................. 115 Robert J. Pawlosky and Norman Salem Jr. 8 Quantifying and Imaging Brain Phospholipid Metabolism In Vivo Using Radiolabeled Long Chain Fatty Acids ............. 125 Stanley I. Rapoport 9 Carbon Recycling: An Important Pathway in ????-Linolenate Metabolism in Fetuses and Neonates....................................... 145 Stephen C. Cunnane CONTENTS xix Part III DHA and CNS Development 10 Impact of Dietary Essential Fatty Acids on Neuronal Structure and Function .............................................................................159 M. Thomas Clandinin, R.A.R. Bowen, and Miyoung Suh 11 Dietary N-3 Fatty Acid Deficiency and its Reversibility: Effects upon Brain Phospholipids and the Turnover of Docosahexaenoic Acid in the Brain and Blood ................... 177 William E. Connor, Gregory J. Anderson, and Don S. Lin 12 The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function ................................................................... 193 Algis J. Vingrys, James A. Armitage, Harrison S. Weisinger, B.V. Bui, Andrew J. Sinclair, and Richard S. Weisinger 13 Brightness–Discrimination Learning Behavior and Retinal Function Affected by Long-Term ????-Linolenic Acid Deficiency in Rat ........................................219 Harumi Okuyama, Yoichi Fujii, and Atsushi Ikemoto Part IV Pathology 14 Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes ....................................... 239 Joseph Eichberg and Cristinel Mîinea 15 Docosahexaenoic Acid Therapy for Disorders of Peroxisome Biogenesis ........................................................ 257 Hugo W. Moser and Gerald V. Raymond 16 Effects of Fatty Acids and Ketones on Neuronal Excitability: Implications for Epilepsy and its Treatment ............................ 273 Carl E. Stafstrom 17 Fatty Acid Ethyl Esters: Toxic Nonoxidative Metabolites of Ethanol.............................291 Zbigniew M. Szczepiorkowski and Michael Laposata Part V Psychiatry and Behavior 18 Omega-3 Fatty Acids and Psychiatric Disorders: Current Status of the Field .......................................................311 Joseph R. Hibbeln and Norman Salem Jr. 19 Disorders of Phospholipid Metabolism in Schizophrenia, Affective Disorders, and Neurodegenerative Disorders .......... 331 David F. Horrobin 20 Eicosapentaenoic Acid: A Potential New Treatment for Schizophrenia? ...................... 345 Malcolm Peet and Shaun Ryles 21 The Importance of DHA in Optimal Cognitive Function in Rodents ................................................................................. 357 Claus C. Becker and David J. Kyle xx Contents 22 The Role of Omega-3 Polyunsaturated Fatty Acids in Body Fluid and Energy Homeostasis ................................... 377 Richard S. Weisinger, James A. Armitage, Peta Burns, Andrew J. Sinclair, Algis J. Vingrys, and Harrison S. Weisinger 23 PUFA: Mediators for the Nervous, Endocrine, and Immune Systems ................................................................. 403 Shlomo Yehuda, Sharon Rabinovitz, and David I. Mostofsky Glossary ...................................................................................................................... 421 Index ........................................................................................................................ 425