Hereditary Colorectal Cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Miguel A Rodriguez-Bigas; Raul Cutait; Patrick M Lynch; Ian Tomlinson; Hans F A Vasen
- ناشر : Boston, MA : Springer Science+Business Media, LLC
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9781441966032
Description
History: family adenomatous polyposis -- Historical aspects of Lynch syndrome -- Molecular genetics of familial adenomatous polyposis -- DNA mismatch repair -- Basic sciences and genetics: hamartomatous polyposis -- Hyperplastic polyposis syndrome : colorectal cancer predisposition -- MUTYH-associated polyposis -- Polymorphic variation and risk of colorectal cancer -- The pathologist and the phenotype of hereditary colorectal cancer -- Genotype phenotype correlation in familial adenomatous polyposis -- Surgery for familial adenomatous polyposis -- Duodenal adenomas in familial adenomatous polyposis -- FAP-associated desmoid tumors -- Attenuated familial adenomatous polyposis : diagnosis, management, and future prognosis -- An overview of the Lynch syndrome (hereditary non-polyposis colorectal cancer) -- Surgical management in Lynch syndrome -- Extracolonic tumors -- Surveillance -- MUTYH-associated polyposis -- Peutz-Jeghers syndrome -- Clinical aspects of juvenile polyposis -- Hereditary mixed polyposis syndrome and multiple adenoma patients -- Hyperplastic polyposis -- Genetic counseling overview -- Across culture and health systems : Europe -- Across culture and health systems: Asia (Hong Kong) -- Across culture and health systems: Asia (Japan) -- Across culture and health systems : Africa -- Across culture and health systems : Argentina -- Genetic counseling across culture and health systems : Australia -- Across culture and health systems : Korea -- Across culture and health systems : America -- Psychological impact of genetic counseling and testing for hereditary colorectal cancers -- Chemoprevention for inherited colorectal cancer -- Registries.
Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6percent, however patients with a familial risk (with two or more first or second degree relatives) make up 20percent of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
