Cardiac electrophysiology methods and models
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniel C Sigg; et al
- ناشر : New York ; London : Springer
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9781441966582
Description
Basic cardiac electrophysiology: excitable membranes -- Cardiac action potentials, ion channels, and gap junctions -- Anatomy and physiology of the cardiac conduction system -- The electrocardiogram and clinical cardiac electrophysiology -- Clinical cardiac electrophysiology : an overview of its evolution -- Principles of electrophysiological in vitro measurements -- Cardiac cellular electrophysiological modeling -- Computer modeling of electrical activation : from cellular dynamics to the whole heart -- Detection and measurement of cardiac ion channels -- Cell culture models and methods -- Isolated tissue models -- Isolated heart models -- Small animal models for arrhythmia studies -- Use of large animal models for cardiac electrophysiology studies -- Optical mapping and calcium imaging -- Electrophysiology of single cardiomyocytes : patch clamp and other recording methods -- Invasive electroanatomical mapping and navigation -- Cardiac electrophysiological imaging : solving the inverse problem of electrocardiography -- Traditional electrophysiological mapping -- Multi-channel system for analysis of cardiac rhythmicity and conductivity in vitro -- Cardiac CT/MRI imaging for electrophysiology -- Introduction to translational research -- Clinical perspective : electrophysiology in the young and patients with congenital heart disease.
Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, ph
