Biomarkers of environmentally associated disease : technologies, concepts, and perspectives

Section I: Overview Chapter 1 Overview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health ...............................................................................................3 William A. Suk and Samuel H. Wilson Chapter 2 Ethical and Legal Considerations in Biological Markers Research..........................................................................................17 Richard R. Sharp and Paul H. Zigas Chapter 3 Scientific and Policy Issues Affecting the Future of Environmental Health Sciences .............................................27 Bernard D. Goldstein Section II: Genomics-Based Biomarkers/Genetic Toxicology Biomarkers Chapter 4 Ecogenetics: Genetic Susceptibility to Environmental Adversity........................................................................................39 Daniel W. Nebert Chapter 5 Toxicogenomics and Pharmacogenomics: Basic Principles, Potential Applications, and Issues.............................................55 F. Peter Guengerich Chapter 6 Individual Susceptibility to Exposures: A Role for Genetic Variation in DNA Repair Genes ..................................63 Harvey W. Mohrenweiser Chapter 7 Studies of DNA Repair and Human Cancer: An Update ............................................................................................83 Marianne Berwick, Giuseppe Matullo, and Paolo Vineis Chapter 8 DNA Adducts as Biomarkers of DNA Damage in Lung Cancer............................................................................109 Suryanarayana V. Vulimiri and John DiGiovanni Chapter 9 Tamoxifen–DNA Adducts: Biomarkers for Drug-Induced Endometrial Cancer....................................................................127 Shinya Shibutani, Naomi Suzuki, and Arthur P. Grollman Chapter 10 Polycyclic Aromatic Hydrocarbon DNA Adducts and Human Cancer ............................................................................139 Mikhail F. Denissenko, Moon-shong Tang, and Gerd P. Pfeifer Chapter 11 Quantitative PCR: A Sensitive Biomarker of Gene-Specific DNA Damage and Repair .........................................................159 Bennett Van Houten, Yiming Chen, Janine H. Santos, and Bhaskar S. Mandavilli Chapter 12 Fidelity of DNA Synthesis as a Molecular Biomarker .........171 Kandace Williams Chapter 13 Mutational Specificity of Environmental Carcinogens.........183 Kathleen Dixon and Mario Medvedovic Section III: Biomarkers of Metal Metabolism Chapter 14 Learning-Induced Modulation of Neural Cell Adhesion Molecule Polysialylation State as a Biomarker of Prior Inorganic Lead Exposure during the Early Postnatal Period .......................................................................... 211 Keith J. Murphy, Helen C. Gallagher, and Ciaran M. Regan Chapter 15 Molecular Biomarkers for Mercury .........................................225 Thomas W. Clarkson and Nazzareno Ballatori Chapter 16 Validity of Mercury Exposure Biomarkers.............................235 Philippe Grandjean, Poul J. Jّrgensen, and Pلl Weihe Chapter 17 Urinary Arsenic Species in Relation to Drinking Water, Toenail Arsenic Concentrations and Genetic Polymorphisms in GSTM1 in New Hampshire ....................249 Margaret R. Karagas, Heather H. Nelson, Karl T. Kelsey, Steven Morris, Joel D. Blum, Tor D. Tosteson, Mark Carey, Xiufen Lu, and X. Chris Le Chapter 18 Molecular Responses of Mammalian Cells to Nickel and Chromate Exposure ............................................................261 Max Costa, Konstantin Salnikow, Jessica E. Sutherland, Thomas Kluz, Wu Peng, and Moon-shong Tang Chapter 19 Chromium: Exposure, Toxicity, and Biomonitoring Approaches ..................................................................................267 Anatoly Zhitkovich Chapter 20 Using Plankton Food Web Variables as Indicators for the Accumulation of Toxic Metals in Fish..............................287 Carol L. Folt, Celia Y. Chen, and Paul C. Pickhardt Section IV: Organ and Systems Biomarkers Chapter 21 Validation of Exposure and Risk Biomarkers: Aflatoxin as a Case Study ...........................................................................307 John D. Groopman, Peta E. Jackson, Paul Turner, Christopher P. Wild, and Thomas W. Kensler Chapter 22 Biomarkers of Early Effect in the Study of Cancer Risk................................................................................................319 Laura Gunn, Luoping Zhang, Matthew S. Forrest, Nina T. Holland, and Martyn T. Smith Chapter 23 Proteomics in Toxicology: An Experience with Gentamicin...................................................................................335 Sandy Kennedy, M.D. Kelly, C. Moyses, R. Amess, and R. Parekh Chapter 24 Xenopus laevis Genomic Biomarkers for Environmental Toxicology Studies ......................................................................339 Perry J. Blackshear Chapter 25 Molecular Biomarkers Targeting Signal Transduction Systems: The AH Receptor Pathway.......................................355 Timothy R. Fennell, Frederick J. Miller, and William F. Greenlee Chapter 26 Measuring Oxidative Damage Caused by Environmental Stressors: Potential for Reversal and Abatement ..................365 Robert A. Floyd Chapter 27 Biomarkers of Male Reproductive Health..............................387 Anne L. Golden Chapter 28 Peripheral Benzodiazepine Receptors: Molecular Biomarkers of Neurotoxicity..................................................... 411 Tomلs R. Guilarte Section V: Biomarkers and Chemical Toxicants Chapter 29 Biomarkers of Organ Injury from Chemical Exposure: Concurrent Inflammation as a Determinant of Susceptibility................................................................................431 Robert A. Roth and Patricia E. Ganey Chapter 30 Modulation of GAP Junctional Communication by “Epigenetic” Toxicants: A Shared Mechanism in Teratogenesis, Carcinogenesis, Atherogenesis, Immunomodulation, Reproductive and Neurotoxicities ...........................................445 James E. Trosko, Chia-Cheng Chang, and Brad Upham Chapter 31 Exposure to POPs and Other Congeners ...............................455 Stephen H. Safe Chapter 32 Polybrominated Diphenyl Ethers: Route, Dose, and Kinetics of Exposure to Humans .............................................471 إke Bergman, Lars Hagmar, Peter Hِglund, and Andreas Sjِdin Chapter 33 Bioanalytical Approaches for the Detection of Dioxin and Related Halogenated Aromatic Hydrocarbons......................483 Michael S. Denison, Scott R. Nagy, Michael Ziccardi, George C. Clark, Michael Chu, David J. Brown, Guomin Shan, Yukio Sugawara, Shirley J. Gee, James Sanborn, and Bruce D. Hammock Chapter 34 Application of Biomarkers to Population Studies on Food Chain Contaminants in Nunavik (Arctic Quebec, Canada).........................................................................................495 ةric Dewailly, Pierre Ayotte, Marc Rhainds, Suzanne Bruneau, Chris Furgal, Jacques Grondin, Benoît Lévesque, Carole Blanchet, Daria Pereg, and Gina Muckle Chapter 35 University-Community Partnership for the Study of Environmental Contamination at Akwesasne...................507 David O. Carpenter, Alice Tarbell, Edward Fitzgerald, Michael J. Kadlec, David O’Hehir, and Brian Bush Section VI: Nanotechniques and Biomarkers Chapter 36 Electronic Biosensing..................................................................527 G.R. Facer, O.A. Saleh, D.A. Notterman, and L.L. Sohn Chapter 37 Two-Photon Fluorescence Microscopy: A Review of Recent Advances in Deep-Tissue Imaging ........................549 Chen-Yuan Dong, Lily Hsu, Ki-Hean Kim, Christof Buehler, Peter D. Kaplan, Thomas D. Hancewicz, and Peter T.C. So Index .....................................................................................................................565