MTOR pathway and mTOR inhibitors in cancer therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Vitaly A Polunovsky; Peter J Houghton
- ناشر : New York : Humana Press
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9781603272711
Description
mTORC1: a signalling integration node involved in cell growth --
The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions --
mTOR signaling in angiogenesis --
mTORC1 signaling and hypoxia --
mTOR signaling in glioblastoma: lessions learned from bench to bedside --
mTOR and cancer therapy: general principles --
mTOR and cancer therapy: clinical development and novel prospects --
Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer --
Downstream targets of mTORC1 --
Downstream of mTOR: translational and control of cancer --
Genome-wide analysis of translational control --
Translational control of cancer: implications for targeted therapy --
Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
