Biotechnology and genetic engineering reviews : Volume 26

List of contributors ix The antibody paradigm: present and future development as a scaffold for biopharmaceutical drugs 1 Roy Jefferis School of Immunity & Infection, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT UK Transgenic plants and associated bacteria for phytoremediation of chlorinated compounds 43 Benoit Van Aken 1,* and Sharon Lafferty Doty2 1 Department of Civil and Environmental Engineering, Temple University, Philadelphia, PA. 2 College of Forest Resources, University of Washington, Seattle, WA Defense and death responses to pore forming toxins 65 Angeles Cancino-Rodezno, Helena Porta, Mario Soberón and Alejandra Bravo* Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ap postal 510-3 CP 62250, Cuernavaca, Morelos, México. Biomedical application of plasmid DNA in gene therapy: A new challenge for chromatography 83 F. Sousa, L. Passarinha, J.A. Queiroz* CICS – Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6201-001 Covilhã, Portugal Three-Dimensional Cell Cultures in Toxicology 117 Francesco Pampaloni1* And Ernst H. K. Stelzer1 1Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117, Heidelberg, Germany Biosynthesis and Engineering of Carotenoids and Apocarotenoids in Plants: State of the Art and Future Prospects 139 Carlo Rosati1*, Gianfranco Diretto2, Giovanni Giuliano2 1Ente per le Nuove tecnologie, l’Energia e l’Ambiente (ENEA), Trisaia Research Center, S.S. 106 km 419.5, 75026 Rotondella (Matera), Italy and 2ENEA, Casaccia Research Center, PO Box 2400, 00123 S.M. di Galeria (Roma), Italy Supply of Nutrients to Cells in Engineered Tissues 163 Jeroen Rouwkema*1, Bart F.J.M. Koopman1, Clemens A. van Blitterswijk2, Wouter J.A. Dhert3,4 and Jos Malda3 1Department of Biomechanical Engineering, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands. 2Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands. 3Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands. 4Faculty of Veterinary Medicine, Utrecht University, The Netherlands Synthesizing Ne urophysiology, Genetics, Behaviour and Learning to Produce Whole -Insec t Progr ammable Sensors to Detect Volatile Chemicals 179 Glen C. Rains1*, Don KUlasiri2, Zhongkun Zhou2, Sandhya Samarasinghe2, JeffeRy K. Tomberlin3, Dawn M. olson4 1University of Georgia, Tifton Campus, Biological and Agricultural Engineering Dept., Tifton, GA 31793, USA; 2Lincoln University, Centre for Advanced Computational Solutions (C-facs), ChristChurch, New Zealand; 3Texas A&M University, Entomology Dept, College Station, TX, 77843, USA; 4USDA-ARS, Crop Protection and Management Research Unit, Tifton, GA, 31794, USA Microbial Transglutaminase Production: Understanding the Mechanism 205 Dongxu Zhang1, Yang Zhu2 and Jian Chen1* 1Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China; 2 Department of Biosciences, TNO Quality of Life, Netherlands Organization for Applied Scientific Research, P.O. Box 360, 3700 AJ Zeist, Netherlands 2A to the Fore – Research, Technology and Applications 223 Garry A. Luke1*, Helena Escuin2, Pablo De Felipe3 And Martin D. Ryan1 1Centre for Biomolecular Sciences, School of Biology, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK; 2Department of Surgery, University of California at Los Angeles (UCLA), Los Angeles, CA, USA and 3Spanish Medicines Agency (AEMPS), Parque Empresarial “Las Mercedes”, Campezo 1 - Edificio 8, 28022 Madrid, SPAIN Adv ance s in mRNA Sile ncing and Tr ansge ne Expre ssion: a Gateway to Functional Genomics in Schistosomes 261 Elissaveta B. Tchoubrieva And Bernd H. Kalinna* Centre for Animal Biotechnology, Faculty of Veterinary Science, The University of Melbourne, Parkville, 3010 VIC, Australia Metabolic Network-Based Interpretation of Gene Expression Data Elucidates Human Cellular Metabolism 281 Tomer Shlomi Department of Computer Science, Technion – Israel Institute of Technology, Haifa 32000, Israel Stem cell biology and cell transplantation therapy in the retina 297 Fumitaka Osakada1,2,*, Yasuhiko Hirami1,3, Masayo Takahashi1,3 1Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan; 2Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA; 3Department of Ophthalmology, Institute of Biomedical Research and Innovation, 2-2 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan Functional Metagenomics: Recent Adv ances and Future Challenges 335 Ludmila Chistoserdova* Department of Chemical Engineering, University of Washington, Seattle WA The impact of Structural Proteomics on Biotechnology 353 Babu A. Manjasetty*, Andrew P. Turnbull1, Santosh Panjikar2 Proteomics & Bioinformatics Research Group, Research and Industry Incubation Center, Dayananda Sagar Institutions, Bangalore 560 078 India, 1Cancer Research Technology Ltd, Birkbeck College, University of London, London, WC1E 7HX, UK and 2EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany Biotechnology as the engine for the Knowledge- Based Bio-Economy 371 Alfredo Aguilar1*, Laurent Bochereau2 and Line Matthiessen3 1Head of Unit Biotechnologies, Directorate Biotechnologies, Agriculture and Food, Research Directorate General, European Commission, 1049 Brussels, Belgium; 2Head of Section, Science, Technology and Education, Delegation of the European Commission to the United States, 2300 M Street NW, 20037-1434, Washington DC, USA, and 3Head of Unit Horizontal Aspects and Coordination, Directorate Biotechnologies, Agriculture and Food, Research Directorate General, European Commission, B-1049 Brussels, Belgium Patent Reform in the United States 389 *Ann E. Mills and Patti M. Tereskerz Center for Biomedical Ethics and Humanities, Program in Ethics and Policy in Healthcare Systems, University of Virginia, Charlottesville, VA 22901, USA INDEX 407