Industrial biotechnology : sustainable growth and economic success

Contents: Preface. List of Contributors. The Scope and Impact of Industrial Biotechnology. (Wim Soetaert and Erick J. Vandamme) 1 History of Industrial Biotechnology. (Arnold L. Demain) 1.1 Early History. 1.2 The Penicillin Story. 1.3 The Coming of the Cephalosporins. 1.4 The Waksman Era. 1.5 Strain Improvement. 1.6 Semi-Synthetic Antibiotics to Combat Resistant Microbes. 1.7 The Primary Metabolites. 1.8 The Shift from Antibiotics to Pharmacological Agents. 1.9 The Biopharmaceutical Revolution. 1.10 Recombinant Hosts. 1.11 Enzymes. 1.12 Bioconversions. 1.13 Vaccines. 1.14 Systems Microbiology. 2 Industrial Systems Biology. (Jose Manuel Otero and Jens Nielsen) 2.1 Introduction. 2.2 Industrial Biotechnology. 2.3 Market Drivers for Industrial Biotechnology. 2.4 Industrial Systems Biology. 2.5 Metabolic Models. 2.6 Reconstructed Metabolic Network Models. 2.7 Industrial Systems Biology Case Studies. 2.8 Conclusion and Future Perspectives. References. 3 Fermentation Technology. (Yusuf Christi) 3.1 Introduction. 3.2 Types of Fermentations. 3.3 Fermentation Process. 3.4 Fermentation Medium Design. 3.5 Sterilization of Air and Fermentation Medium. 3.6 Environmental Factors. 3.7 Fermentation Kinetics. 3.8 Fermentation Equipment. 3.9 Recovery of Fermentation Products. 3.10 Concluding Remarks. References. 4 Directed Evolution of Industrial Biocatalysts. (Marlen Schmidt, Dominique Bottcher, and Uwe T. Bornscheuer) 4.1 Introduction. 4.2 Strategies for Protein Design. 4.3 Assay Systems. 4.4 Examples. 4.5 Conclusions. References. 5 The Industrial Production of Enzymes. (Reeta Rani Singhania, Anil Kumar Patel, and Ashok Pandey) 5.1 Introduction. 5.2 Enzyme Production. 5.3 Enzyme Improvement. 5.4 Large-Scale Enzyme Applications. 5.5 Conclusions. References. 6 Applied Biocatalysis: An Overview. (Pedro Fernandes and Joaquim M.S. Cabral) 6.1 Introduction. 6.2 The Design of the Bioconversion System. 6.3 Bioreactors. 6.4 Rationalizing and Speeding Up the Development and Characterization of a Bioconversion Process. 6.5 Concluding Remarks. Acknowledgments. References. 7 Nanobiotechnology. (Rudy J. Koopmans) 7.1 Setting the Stage. 7.2 Industrial Perspective. 7.3 Nanotechnology in Biology and Biochemistry. 7.4 Biomimicry. 7.5 Materials and Products. 7.6 Processes and Devices. 7.7 Outlook. References. 8 Downstream Processing in Industrial Biotechnology. (Rajni Hatti-Kaulz) 8.1 Introduction. 8.2 Separations in Industrial Biotechnology. 8.3 Examples of Downstream Processing of Different Product Groups. Acknowledgements. References. 9 Industrial Biotechnology in the Chemical and Pharmaceutical Industries. (Maurice C.R. Franssen, Manfred Kircher, and Roland Wohlgemuth) 9.1 Introduction 9.2 Biocatalytic Processes: Scientific and Technological Perspectives 9.3 Biocatalytic Processes: Business and Commercial Perspective 9.4 Safety, Health, and the Environmental Perspective 9.5 Outlook Acknowledgments. References. 10 Industrial Biotechnology in the Food and Feed Sector. (Pierre Monsan and Michael J. O'Donohue) 10.1 Introduction. 10.2 Food Applications. 10.3 Food and Feed Applications. 10.4 Feed Applications. References. 11 Industrial Biotechnology in the Paper and Pulp Sector. (Liisa Viikari, Stina Gronqvist, Kristiina Kruus, Jaakko Pere, Matti Siika-aho, and Anna Suurnakki) 11.1 Introduction. 11.2 Enzymes for the Pulp and Paper Industry. 11.3 Enzymes as Process Aids. 11.4 Enzymes for Product Design. 11.5 Biorefinery Concepts. 11.6 Conclusions. References. 12 Biofuels: Production and Appliations. (Alexandre Rojey and Frederic Monot) 12.1 A Renewed Interest in Biofuels. 12.2 Present Conversion Pathways. 12.3 Biodiesel Production from Vegetable Oils and Fats. 12.4 Ethanol and ETBE Production. 12.5 The Need for New Developments. 12.6 Lignocellulosic Biomass Resources. 12.7 Production of Ethanol from Lignocellulosic Biomass. 12.8 Production of Biofuels Through the Thermochemical Pathway. 12.9 Biorefineries. 12.10 Biofuels and Sustainability. 12.11 Conclusion. References. 13 Environmental and Economic Aspects of Industrial Biotechnology. (Barbara G. Hermann, Veronika Dornburg, and Martin K. Patel) 13.1 Introduction. 13.2 Methodology. 13.3 Overall Results. 13.4 Conclusions. 13.5 References. 14 Societal Issues in Industrial Biotechnology. (Patricia Osseweijer, Klaus Ammann, and Julian Kinderlerer) 14.1 Introduction. 14.2 The Impact of Industrial Biotechnology. 14.3 Public Perceptions of Industrial Biotechnology. 14.4 Societal Issues in Industrial Biotechnology. 14.5 Conclusions and Discussion: A Joint Agenda for the Smooth Introduction of Acceptable Sustainable Industrial Biotechnology. Acknowledgment. References. Index.