دیابت نوع 1 – پاتوژنز، ژنتیک و ایمنی درمانی Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy

This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered. ---- Table of Contents: -- Autoimmunity and Immunotherapy of Type 1 Diabetes -- Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes -- Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4 -- The Role of T Cells in Type 1 Diabetes -- Beta-Cell Function and Failure in Type 1 Diabetes -- Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders -- Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes -- The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes -- Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling -- Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes -- Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis -- In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes -- Imaging the Pancreatic Beta Cell -- Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus -- Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes -- Immunotherapy for Type 1 Diabetes – Preclinical and Clinical Trials -- Type 1 Diabetes Immunotherapy - Successes, Failures and Promises -- Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities -- Autoantigen-Specific Immunotherapy -- Multi-Component Vaccines for Suppression of Type 1 Diabetes -- Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes -- Beta Cell Replacement Therapy -- Genetics of Type 1 Diabetes -- The Genetics of Type 1 Diabetes -- Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease -- Genetics of Type 1 Diabetes -- Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes -- Genetic Determinants of Type 1 Diabetes