Functional neuroanatomy of pain
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : K G Usunoff; et al
- ناشر : Berlin ; New York : Springer,
- چاپ و سال / کشور: 2006
- شابک / ISBN : 9783540281665
Description
2 Functional Neuroanatomy of the Pain System . . . . . . . . . . . . . . . . . . . . . . 1 2.1 PrimaryAfferentNeuron . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2.2 Distribution ofNociceptor PeripheralEndings . . . . . . . . . . . . . . . . . . . . . . 5 2.3 Termination in the SpinalCord and SpinalTrigeminalNucleus . . . . . . . . . . 9 2.3.1 Types of Terminals in Substantia Gelatinosa . . . . . . . . . . . . . . . . . . . . . . . . 12 2.4 AscendingPathways of the SpinalCord and of the STN . . . . . . . . . . . . . . . . 23 2.4.1 SpinothalamicTract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 2.4.2 Projections to the Ventrobasal Thalamus in the Rat . . . . . . . . . . . . . . . . . . . 26 2.4.3 Pathways to Extrathalamic Structures . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 2.5 DorsalColumnNuclei andNociception . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 2.6 CerebellumandNociception . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 2.7 Cortices Involved in Pain Perception andThalamocortical Projections . . . . . 44 2.8 DescendingModulatory Pathways . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3 Neuropathic Pain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 3.1 CentralChangesConsequent to PeripheralNerve Injury . . . . . . . . . . . . . . . 53 3.2 TheRole ofGlialCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 3.3 Neuropathology ofHerpesZoster and of PostherpeticNeuralgia . . . . . . . . . 59 3.4 DiabeticNeuropathicPain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 3.5 CancerNeuropathicPain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 3.6 CentralNeuropathicPain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 3.6.1 SpinalCordInjury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 3.6.2 Brain Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 3.6.3 Changes inCorticalNetworksDue toChronicPain . . . . . . . . . . . . . . . . . . . 66 4 Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 5 Summary . . . . . . . . .
Pain is an unpleasant, but very important biological signal for danger. Pain is both a sensory experience and a perceptual metaphor for damage, and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain."
