The impact of tumor biology on cancer treatment and multidisciplinary strategies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : M Molls; M S Anscher; et al
- ناشر : Berlin : Springer
- چاپ و سال / کشور: 2009
- شابک / ISBN : 9783540743866
Description
Contents: Tumorigenesis.- Tumor Growth and Cell Proliferation.- Angiogenesis.- Tumor Physiology (Phenomenology).- Adhesion, Invasion, Integrins and Beyond.- Development of Metastases.- Role of the Immune System in Cancer Development and Therapeutic Implications.- Cancer Prevention .- Tumor Detection by Morphological and Biological Imaging.- Tumor Detection by Biological Markers (Serum, Urine, Breathing Gas, Proteomics).- Quantitative Cell Kill by Chemo- and Radiotherapy.- Impact of Molecularly Targeted Agents on Cell Kill in Bi- or Trimodal Approaches (i.e. plus Chemo, Radio-, or Radiochemotherapy).- Translational Studies for Target-Based Drugs.- Molecular Mechanisms of Treatment Resistance.- Physiological Mechanisms of Treatment Resistance.- Influence of Repopulation on Treatment Resistance.- Molecular Tools, Gene Expression Profiling.- Strategies of Gene Transfer/Silencing and Technical Considerations.- Tumor Biology's Impact on Clinical Cure Rates.- Can Dose-Escalated Radiotherapy Eventually Cure All Biologically Distinct Subsets of a Certain Tumor Type? Answers from Stereotactic Lung and Liver Radiotherapy Experience.-Low-Dose Radiotherapy -- A Chemopotentiator?.- Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.- Subject Index.- List of Contributors.
Summary: This text provides a detailed overview of the fundamentals of tumor biology and the influence of biologic factors on the design of therapeutic strategies and the outcome of established and emerging treatments. Particular attention is devoted to multidisciplinary combined modality therapy.
