Pharmacology of neurotransmitter release
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Thomas C Südhof; Klaus Starke; S Boehm; et al
- ناشر : Berlin : Springer
- چاپ و سال / کشور: 2008
- شابک / ISBN : 9783540748052
Description
Front Matter; Neurotransmitter Release; Pharmacology of Neurotransmitter Release: Measuring Exocytosis; Presynaptic Calcium Channels: Structure, Regulators, and Blockers; Pharmacology of Neurotransmitter Transport into Secretory Vesicles; Core Proteins of the Secretory Machinery; Presynaptic Neurotoxins with Enzymatic Activities; a-Latrotoxin and Its Receptors; Presynaptic Signaling by Heterotrimeric G-Proteins; Presynaptic Metabotropic Receptors for Acetylcholine and Adrenaline/Noradrenaline; Presynaptic Receptors for Dopamine, Histamine, and Serotonin.
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book??'s second part, the presynapti.
