Fundamentals of tissue engineering and regenerative medicine

GENERAL ASPECTS: General and ethical aspects: History of tissue engineering in perspective: Economic modeling and decision making in the development and clinical application of tissue engineering.- Ethical issues in tissue engineering.- Sourcing human embryonic stem cells: the ethical issue.- Tissue Engineering and Regenerative Medicine. Aims, Methods, and Results from an ethical Perspective. BIOLOGICAL CONSIDERATIONS: Tissue and organ differentiation: Control of Organogenesis.- Cytokine signalling in tissue Engineering.- Influence of mechanical effects on cells. ENGINEERING STRATEGIES: Engineering at the genetic and molecular level: Towards genetically designed tissues in Regenerative Medicine.- Strategies in regenerative medicine for post-transcriptional gene silencing using RNA interference.- Biomolecule use in tissue engineering. Engineering at the cellular level: Regenerative Capacity of Fetal Stem Cells.- Embryonic cells.- The Unrestricted Somatic Stem Cell (USSC) From Cord Blood For Regenerative Medicine.- Mesenchymal stem cells: New insights into tissue engineering and regenerative medicine.- Stem cell plasticity: Validation vs. valedictory. Engineering at the tissue level: Bone tissue engineering.- Cartilage engineering.- Muscle Tissue Engineering.- Tendon and Ligament Tissue Engineering.- Neural Tissue Engineering and Regenerative Medicine.- Adipose Tissue Engineering.- Intervertebral disc regeneration.- Tissue Engineering of Ligaments and Tendons.- Tissue engineering of cultured skin substitutes.- Dental Hard Tissue Engineering.- Mucosa tissue engineering.- Tissue Engineering of Heart valves. Engineering at the organ level: Breast tissue engineering.- Bioartificial Liver.- Pancreas engineering.- The tissue-engineered urinary bladder.- Cell based regenerative medicine for heart diseases. TECHNICAL ASPECTS: Biomaterial related aspects: Biomaterials.- Biomaterial related approaches- surface structuring.- Mineralised collagen as biomaterial and matrix for bone tissue engineering.- Hydrogels for Tissue Engineering. Scaffold related aspects: Defining Design Targets for Tissue Engineering Scaffolds.- Scaffold structure and fabrication.- Prospects of micromass culture technology in tissue engineering. Laboratory aspects and Bioreactor use: Laboratory proceedings: Culture of cells and tissues.- Bioreactors in tissue engineering: from basic research to automated product manufacturing.- The Evolution of Cell Printing.- Biomagnetic and Bioelectric Stimulation in Bioreactors.- Microenvironmental Determinants of Stem Cell Fate. TRANSPLANTATION ISSUES: Functional aspects in biological engineering: Perfusion Effects and Hydrodynamics.- Ex-vivo formation of vessels.- Biomechanical function in tissue engineering.- Influence of mechanical loads. Immune system issues: Innate and Adaptive Immune Responses in Tissue Engineering.- Toll-like receptors in inflammatory heart disease. Study design principles: Tissue Engineered Models for in vitro Studies.- In vivo models in tissue engineering.- Assessment of Tissue Responses to Tissue Engineered Devices.- CLINICAL USE: Clinical application: State of Clinical Application in Tissue Engineering and Regenerative Medicine.- Tissue Engineering applications in neurology.- Tissue engineering in Maxillofacial Surgery.- Tissue engineering strategies in dental implantology.- Tissue Engineering Application in General Surgery.- Regeneration of Renal Tissues.- Tissue Engineering Applications in Plastic Surgery.- Tissue Engineering Applications for Cardiovascular Substitutes.- Tissue Engineering Applications in Orthopaedic Surgery.- Tissue engineering and its applications in dentistry.- Tissue engineering application in endocrinology.- Regenerative medicine applications in Hematology.- Tissue engineering applications in dermatology. Clinical handling and Regulatory issues: Regulatory issues.