Novel compounds from natural products in the new millennium : potential and challenges

Foreword (by John Wong) ......................................................... xi Foreword (by Kurt Hostettmann) ............................................. xiii Preface .................................................................................... xv 1. Plants in Drug Discovery - Creating a New Vision. ............. 1 Geoffrey Alan Cordell 2. The Bio-Extraction Industry in Jamaica: Potential and Challenges ...................................................................... 20 Trevor Herbert Yee 3. Structural Studies of Drug Metabolising Enzymes and the Relevance to Natural Product Development .................... 30 Rupika Delgodu 4. Bioinformatics - Species Diversity Databases: Tools for Facilitating Natural Product Research ......................... 40 Sudershan Kumar and vidhi Guptu 5. From Genomes to Drugs with Bioinformatics ...................... 58 Kuo-Bin Li 6. Yeast-Based Technologies for High Throughput Screening of Natural Anti-Viral Agents ............................................ 69 Rushi Srivustuvu and Sunil Kumar La1 7. Use of High-Density Oligonucleotide Microarrays for Gene Expression Profiling in Natural Product Research ............. 77 George Wai-Cheong Ep 8. Limitations of Natural Pesticides: AChallenge to Scientists .. 87 Ajai Munsingh 9. Bioactivity of Hexane Extract of Blighia sapida Konig. on the Cattle Tick, Boophilus microplus and the Sweet Potato Weevil, Cylas fomzicarius elegantulus ............. 107 Arlene Wilson and Ajai Munsingh 1.. V l l l Contents 10. Antibacterial Screening of Trugiu involucrutu L. (Euphorbiaceae) - ATribal Used Medicinal Plant ......... 1 12 Ramar Perumal Samy et al. 11. Effect of Crude Papaya Latex on Rats’ Pregnancy ............ 123 Adebowale Adebiyi and P Ganesan Adaikan 12. 1 -Cyano-2-Hydroxy-3-Butene: A Plant Nitrile that Induces Apoptosis in Pancreatic Acinar Cells and Reduces the Severity of Acute Pancreatitis ........................................ 130 Madhav Bhatia and Matthew A Wallig 13. The Liver Protective Effect of Sesamin ............................. 139 Yasuo Kiso and Takatoshi Ishikawa 14. Endothelium-Dependent Vascular Relaxation Induced by Extracts of Some Chinese Medicinal Herbs Traditionally Used to Remove Circulatory Stagnation: An Update ...... 148 Chiu-En Kwan and Paul Chan 15. Effect of Chronic Administration of Aqueous Azadiruchtu indicu (Neem) Leaf Extract on the Cardiovascular System in the Rat .......................................................... 16 1 Idongesit Obiefuna and Ronald Young 16. The Anti-Hypertensive Effect of Sesamin .......................... 170 Yasuo Matsumura 17. Effects of Sulviu miltiorrhizu After Acute Myocardial Infarction in Rats ........................................................... 183 Xin-Yan Ji et al. 18. The Antioxidant and Free Radical Scavenging Effects ofSesamin .................................................................... 196 Toshio Moritani 19. Anticancer and Immunomodulatory Potential of DRF-3 188, an Analogue of Andrographolide ................. 205 Ajaya R Kumar et al. Contents ix 20. Immunomodulating Property of Astrugalus membrunaceus and Curcurnu urornuticu .............................................. 217 Agnes Slater and Benny Kwong-Huat Tan 2 1. Induction of Breast Tumours in Rats for Assaying Natural Products for Anti-Tumour Properties ............................. 222 Janet Marlene Menzie 22. Cancer Diagnosis Using the Novel Photosensitizer, Hypencin ...................................................................... 227 Malini Olivo 23. Chemopreventive Efficacy of Apigenin against N-Nitrosodiethylamine-Induced and Phenobarbital- Promoted Experimental Hepatoma ................................ 237 Dhanapal Sakthisekaran and Jeyapal Prince Kjeya Singh 24. The Effects of Saponin from Sea Cucumber (Holothuriu utru Jaeger) on CEM-SS T-Lymphoblastic Cells.. ......... 247 Hiang-Lian Hing et al. 25. Lentinan - AMedicaUy Valuable Glucan ......................... 254 Ann-Teck Yap and Mah-Lee Ng 26. Turmeric and Colon Cancer ............................................. 266 Devasena Thiyagarajan et al. 27. Immunotherapy of Bladder Cancer Using Microbes.. ........ 280 Ratha Mahendran et al. 28. Modulation of Hypericin-Based Phototoxicity in Nasopharyngeal Cancer ................................................ 290 Hong-Yan Du et al. 29. Research and Development of Natural Products in Developing Countries: Need for Venture Capital ............ 302 Victor Hugo Rhone 30. Protection of Ideas, Inventions, Trade Marks, Copyrights and Products under the Intellectual Property Law .......... 3 12 Catherine Swee-Kian Tay Index of Contributors .............................................................