Comparative study on the acceptability of two modern monophasic oral contraceptive preparations: 30 mg ethinyl estradiol combined with 150 mg desogestrel or 75 mg gestodene
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : L. ZICHELLA (1), C. SBRIGNADELLO (2), A. TOMASSINI (3), A. DI LIETO(4), C. MONTONERI (5), G. ZARBO (5), M. MANCONE (1),P. PIETROBATTISTA (1), G. BERTO
- چاپ و سال / کشور: 2000
Description
containing 30 mg ethinyl estradiol (EE) with either 150 mg desogestrel (DSG) or 75 mg gestodene (GSD) were compared in women starting oral contra- ception. A minimum of 200 healthy women at risk for pregnancy were to be treated for a total of 6 cycles per patient in a prospective, randomized open parallel- group multicenter trial. Two hundred and forty-one subjects were randomized, 115 to DSG/EE and 126 to GSD/EE. Compliance to the study preparation was high (around 95%) in both groups and no pregnancies occurred during the study. Cycle control was excellent; there were no di،erences between the two groups with regard to incidence of spotting and breakthrough bleeding or duration and intensity of withdrawal bleeding. Side-e،ects were mild and in general comparable in the two groups. Both at baseline and during treatment, a higher proportion of women taking GSD/EE complained about breast tenderness. This resulted in more early withdrawals because of breast tenderness in the GSD/EE group.It was concluded that monophasic DSG/EE and GSD/EE are equally e،ective, have similar cycle control and both are generally well tolerated.
Advances in Contraception, 1999; 15: 191^200. #2000Kluwer Academic Publishers. Printed in theNetherlands
