Antifertility e،ect of aqueous extract of seeds of Cassia ¢stula in female rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : R. YADAV and G.C. JAIN*
- چاپ و سال / کشور: 2000
Description
Oral administration of aqueous extract of seeds of Cassia ¢stula to mated female rats from day 1^5 of pregnancy at the doses of 100 and 200 mg/kg body weight resulted in 57.14% and 71.43% prevention of pregnancy, respectively, whereas 100% pregnancy inhibition was noted at 500 mg/kg bw. In the uterine bioassay test carried out in immature bilaterally ovariectomized female rats, aqueous extract of seeds of Cassia ¢stula (100 mg/kg bw) increased the uterine wet weight (p50.05) and luminal epithelial cell height (p50.001) but did not induce premature opening of the vagina. This suggests a mild estrogenic activity of the extract. However, when the extract was administered conjointly with estradiol valerate (EDV, 0.1 mg/kg bw), it signi¢cantly (p50.001) prevented the estrogen-induced uterotrophic e،ect, thus showing an antiestro- genic nature of the extract in the presence of a strong estrogen
Advances in Contraception, 1999; 15: 293^301. #2000Kluwer Academic Publishers. Printed in theNetherlands
