Early abortion by mifepristone (RU 486) followed by vaginal gel (meteneprost) versus oral (misoprostol) prostaglandin
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : D. TAKKAR, N. AGARWAL*, R. SEHGAL and K. BUCKSHEE
- چاپ و سال / کشور: 1999
Description
The present study was conducted to compare the therapeutic regimens of low- dose mifepristone (200 mg) plus vaginal meteneprost versus oral misoprostol in terms of e¤cacy and safety for medical termination of early pregnancy. A randomized clinical trial was conducted by the Department of Obstetrics and Gynecology at the All India Institute of Medical Sciences, New Delhi. A total of 101 subjects were enrolled within 56 days of amenorrhea. A single dose of 200 mg of mifepristone (RU 486) was given and, 48 hr later, prostaglandin was administered as either 5 mg of 9 methylene PGE2 vaginal gel, meteneprost (classi¢ed as group I) or 600 mg of oral PGE1 derivative misoprostol (classi¢ed as group II). In group I, 50 subjects and in group II, 51 subjects were treated with the respective schedule. The success rate with mifepristone + misoprostol (group II) was 88.63% which was signi¢cantly higher than that with mifepris- tone + meteneprost (group I) which was 82% (p50.05). The average duration of bleeding in cases with complete abortion was 8.95+5.67 and 9.77+6.51 in group I and II, respectively. There were no serious side-e،ects. Only one subject in group I (2%) required blood transfusion for heavy bleeding. This study indicated that oral prostaglandin after a low dose of mifepristone (200 mg) could be developed into an e،ective method to terminate early pregnancy. Oral administration of both drugs would be a more convenient, feasible, private and acceptable regimen.
Advances in Contraception, 1999; 15: 163^173. #1999Kluwer Academic Publishers. Printed in theNetherlands
