Mutations in the Epidermal Growth Factor Receptor Gene in Non-Small Cell Lung Cancer: Impact on Treatment Beyond Gefitinib and Erlotinib
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : David F, Heigener , Martin Reck
- چاپ و سال / کشور: 2010
Description
Epidermal growth factor receptor (EGFR)- activating mutations in non-small cell lung cancer (NSCLC) are molecular targets for treatment with gefitinib and erlotinib, often resulting in improved response and prolonged progression-free survival. Resistance to these drugs, which develops during treatment, is a problem of paramount importance. Several mechanisms of “acquired resistance” have been discovered and treatments for this specific entity are on the horizon.
Adv Ther (2011) 28(2):126-133. DOI: 10.1007/s12325-010-0096-4 Received: September 28, 2010 / Published online: December 16, 2010
