Reduced Thrombin Generation and Soluble P-selectinAfter Intravenous Enoxaparin During PCI
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J. Kvasnièka , J. Horلk , Z. Zenلhlیkovل , Tomلڑ Kvasnièka , S. ٹimek , T. Kovلrnیk , I. Malیkovل , A. Linhart , M. Aschermann
- چاپ و سال / کشور: 2011
Description
Purpose The objective of our study was to identify changes in the coagulation and serum concentration of soluble P-selectin (sP-sel) after i.v. bolus of 0.75 mg/kg enoxaparin in a group of 33 patients during PCI. Methods and results As compared to baseline, i.v. enoxaparin increased anti -Xa activity and FIIa inhibition together with APTT and thrombin time tests within 20 min, that persisted for 60 min. At 6 h, the results of all tests had returned to baseline. In contrast, the level of prothrombin fragments (F1+2) decreased persistingly for a period of 6 h (baseline 1.19±0.42 nmol/l, after 20 min 1.03±0.46 nmol/l, after 60 min 1.06±0.43 nmol/l, after 6 h 0.95±0.40 nmol/l, p<0.001 vs. baseline for all values). In addition, i.v. enoxaparin decreased serum sP-sel level (baseline 111.80± 37.05 ng/ml, after 20 min 87.80±33.17 ng/ml, after 60 min 86.45±29.15 ng/ml, after 6 h 92.24±31.34 ng/ml, p<0.001 vs. baseline value for all). sP-sel level mildly correlated with both F Xa inhibition (r=-0.275, p<0.05) and F1+2 level (r=0.274, p<0.05). Conclusion Intravenous enoxaparin induced target F Xa inhibition (>0.6 IU/ml) for 60 min in 82% of study patients. During the 6 h of monitoring, a decrease of thrombin generation (F1+2) and sP-selectin levels were observed.
Cardiovasc Drugs Ther (2011) 25:243–250 Published online: 17 May 2011
