Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Giuseppina Tiziana Russo, Antonino Di Benedetto, Domenico Magazzu` , Annalisa Giandalia , Carlo Bruno Giorda , Riccardo Ientile, Marcello Previti ,
- چاپ و سال / کشور: 2009
Description
The role of hyperhomocysteinemia as a risk factor for diabetic long-term complications has not been sufficiently evaluated in prospective studies, considering specific correlates of homocysteine (tHcy) concentration and traditional cardiovascular disease (CVD) risk factors. Fasting tHcy, vitamin B12 and folate plasma levels, the common methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, as well as clinical and lifestyle information were assessed in 216 type 2 diabetic patients attending two outpatient clinics, who had a follow-up evaluation at 65 ± 9 months for the incidence of macroangiopathy. At basal evaluation, mild hyperhomocysteinemia (tHcy C 15 lmol/l) was diagnosed in 21.3% of participants. At follow-up, hyperhomocysteinemia and the distribution of MTHFR C677T genotype did not significantly differ according to the incidence of macroangiopathy. Multiple variables adjusted ORs (95% CI) for CVD associated with mild hyperhomocysteinemia were 1.01 (0.37–2.82); P[0.05; those associated with MTHFR TT genotype were 0.46 (0.15–1.38); P[0.05. Although the prevalence of hyperhomocysteinemia was higher in diabetic men (26.9%) than in women (16.1%; P[0.05), similar results were also observed in a separate sexanalysis. At the multivariate analysis, including in the model other potential CVD risk factors, only creatinine clearance was a significant risk factor for the development of macroangiopathy. In this cohort of diabetic subjects, mild hyperhomocysteinemia and the MTHFR TT genotype are not significant risk factors for the development of macroangiopathy; impaired renal function was confirmed as a significant predictor of this complication.
Acta Diabetol (2011) 48:95–101 DOI 10.1007/s00592-009-0169-5 Received: 7 August 2009 / Accepted: 5 November 2009 / Published online: 25 November 2009 Springer-Verlag 2009
