Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sheng-Chiang Su, Dee Pei , Chang-Hsun Hsieh , Fone-Ching Hsiao , Chung-Ze Wu, Yi-Jen Hung
- چاپ و سال / کشور: 2010
Description
This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI225 kg/m2, N = 23) and an obese group (OBYDM, BMI325 kg/m2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) were determined. Insulin sensitivity and b-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-b, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P\0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P\0.01 and P\0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-a levels in OBYDM, whereas higher TNF-a and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = -0.44, P\0.005), CRP (R = 0.28, P\0.05), TNF-a (R = 0.42, P\0.005) and IL-6 (R = 0.33, P\0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = -0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.
Acta Diabetol (2011) 48:113–119 DOI 10.1007/s00592-009-0171-y Received: 9 February 2009 / Accepted: 10 December 2009 / Published online: 8 January 2010 Springer-Verlag 2009
