Markedly increased serum and urinary fructose concentrations in diabetic patients with ketoacidosis or ketosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Takahiro Kawasaki Kanji Igarashi Nobuyuki Ogata Yoko Oka Kaoru Ichiyanagi Toshikazu Yamanouchi
- چاپ و سال / کشور: 2010
Description
To investigate fructose concentrations in diabetic patients with ketoacidosis or ketosis, serum fructose concentrations and daily urinary fructose excretion were measured in 23 patients with ketoacidosis (n = 16) and ketosis (n = 7) on the first day of admission. Seventeen patients were diagnosed with type 1, one patient with mitochondrial, and 4 patients with atypical diabetes. In 16 of the 23 patients, serum and urinary fructose could be assessed after starting treatments. Mean serum fructose concentration was 71.6 ± 108.1 lmol/l, and mean daily urinary fructose excretion was 352.1 ± 473.7 lmol/day. Serum fructose levels in patients with atypical diabetes were much higher (205.0 ± 213.3 lmol/l) than those in patients with type 1 diabetes (45.1 ± 44.5 lmol/l), while urinary fructose levels in atypical diabetes (249.7 ± 92.4 lmol/day) tended to be lower than those in type 1 diabetes (382.6 ± 533.2 lmol/day). Serum fructose concentrations decreased significantly (P\0.05) from 88.1 ± 126.3 to 18.0 ± 11.0 lmol/l, and daily urinary fructose excretion also decreased significantly (P\0.05) from 459.8 ± 530.9 to 75.1 ± 62.0 lmol/day in accordance with glycemic normalization after treatment. Marked and reversible increases in serum and urinary fructose concentrations were observed in diabetics with ketoacidosis and ketosis.
Received: 4 September 2009 / Accepted: 8 February 2010 Springer-Verlag 2010 Acta Diabetol DOI 10.1007/s00592-010-0179-3
