The predictive value of TNF-a and IL-6 and the incidence of macrovascular complications in patients with type 2 diabetes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Weihua Wu Mingli Wang Zhenjie Sun Xin Wang Jiajing Miao Zhaohui Zheng
- چاپ و سال / کشور: 2010
Description
Some inflammation factors have been shown to accelerate type 2 diabetes macrovascular complication (T2DMC). The study investigates the variation of TNF-a and IL-6 levels during the progression of T2DMC to explore their predictive value in the incidence of T2DMC. All participants were divided into two groups, type 2 diabetes mellitus (T2DM) and non-diabetes (ND) group. TNF-a and IL-6 were analyzed with enzyme immunoassay. All participants were followed up by carotid Doppler, Doppler of lower extremities, head CT and 64-row multislice spiral CTA. The incidence of macrovascular atherosclerosis in T2DM was significantly higher than that in ND group (P\0.05). The levels of TNF-a and IL-6 in both groups with atherosclerosis increased annually. In patients who had atherosclerosis with diabetes, measured levels of TNF-a and IL-6 were significantly higher than those in patients with atherosclerosis without diabetes (P\0.05). The levels of TNF-a and IL-6 in T2DMC and ND group with atherosclerosis was significantly higher than that in two groups without atherosclerosis (P\0.05). Patients with T2DM were divided into four groups according to their HbA1C level. There was a strong positive correlation between the levels of TNF-a and IL-6 and HbA1C (P[0.05). The TNF-a and IL-6 levels can be used as predictors for atherosclerosis development. Compared with non-diabetic atherosclerosis, TNF-a and IL-6 have stronger predictive value in diabetic atherosclerosis development. One reason for hyperglycemia increasing atherosclerosis is to activate inflammatory cells and relives of inflammatory factors. Hyperglycemia can trigger inflammation, which is a quality–effect relationship reaction
Acta Diabetol DOI 10.1007/s00592-010-0198-0 Received: 14 December 2009 / Accepted: 5 May 2010 Springer-Verlag 2010
