G6PD deficiency-induced hemolysis in a Chinese diabetic patient: a case report with clinical and molecular analysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Xue-Jiang Gu Shuo-Ping Chen Sheng-Jie Ge Le-Qun Zheng Da-Wang Wang Fei-Xia Shen
- چاپ و سال / کشور: 2010
Description
A 59-year-old Chinese male patient was admitted at diagnosis of type1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of glucose-6-phosphate dehydrogenase (G6PD). DNA analysis did not show any coding or intronic mutation in the G6PD gene. This is the first reported case of a Chinese patient in diabetic ketoacidosis with hemolysis induced by G6PD deficiency in the absence of mutations in the G6PD gene.
Received: 30 July 2010 / Accepted: 27 October 2010 Springer-Verlag 2010 Acta Diabetol DOI 10.1007/s00592-010-0236-y
