The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Valeria Calcaterra Miryam Martinetti Alessandro Salina Concetta Aloi Daniela Larizza
- چاپ و سال / کشور: 2011
Description
Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulinresistance due to overweight is more reminiscent of type 2 diabetes, some studies have described b-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of immune and metabolic dysfunction modified by genetic factors.
Acta Diabetol DOI 10.1007/s00592-011-0300-2 Received: 5 May 2011 / Accepted: 2 June 2011 Springer-Verlag 2011
