Deep brain stimulation and frameless stereotactic radiosurgery in the treatment of bilateral parkinsonian tremor: target selection and case report of two patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Angelo Franzini , Marcello Marchetti , Lorenzo Brait , Ida Milanesi , Giuseppe Messina , Elisabetta Forapani , Giovanni Broggi , Laura Fariselli
- چاپ و سال / کشور: 2011
Description
Considerable positive experience in functional radiosurgery has been reported since Leksell’s first experience in 1951, but the development of frameless radiosurgery was been limited because of the difficulty of identifying invisible functional targets. In this paper we report on two cases of bilateral parkinsonian tremor successfully treated with DBS on one side and with frameless radiosurgery on the contralateral side. We focus on the methodology developed to define the three-dimensional target coordinates for frameless radiosurgery. Two patients suffering from a disabling upper-limb parkinsonian tremor underwent frameless radiosurgical thalamotomy. To accurately identify the treatment target the CT gantry was treated as a stereotactic frame; a rototranslation between the origin of the screen and the origin of the stereotactic atlas allowed us to obtain atlas-registered 3D coordinates of each point on the CT axial brain slices. Both patients achieved complete bilateral tremor control by unilateral radiosurgery and contralateral DBS. We developed a method for determining the 3D coordinates of a known functional target to treat with frameless radiosurgery. Based on the initial experiences, frameless radiosurgery appears to be an alternative treatment for Parkinsonian upper limb tremor in the presence of increased surgical risks for DBS placement.
Acta Neurochir (2011) 153:1069–1075 DOI 10.1007/s00701-011-0962-Received: 4 November 2010 / Accepted: 31 January 2011 / Published online: 20 February 2011 # Springer-Verlag 2011
